Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.

Publication ,  Journal Article
Mural, RJ; Adams, MD; Myers, EW; Smith, HO; Miklos, GLG; Wides, R; Halpern, A; Li, PW; Sutton, GG; Nadeau, J; Salzberg, SL; Holt, RA; Lu, F ...
Published in: Science
May 31, 2002

The high degree of similarity between the mouse and human genomes is demonstrated through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained as part of a whole-genome shotgun assembly of the mouse genome. The mouse genome is about 10% smaller than the human genome, owing to a lower repetitive DNA content. Comparison of the structure and protein-coding potential of Mmu 16 with that of the homologous segments of the human genome identifies regions of conserved synteny with human chromosomes (Hsa) 3, 8, 12, 16, 21, and 22. Gene content and order are highly conserved between Mmu 16 and the syntenic blocks of the human genome. Of the 731 predicted genes on Mmu 16, 509 align with orthologs on the corresponding portions of the human genome, 44 are likely paralogous to these genes, and 164 genes have homologs elsewhere in the human genome; there are 14 genes for which we could find no human counterpart.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Science

DOI

EISSN

1095-9203

Publication Date

May 31, 2002

Volume

296

Issue

5573

Start / End Page

1661 / 1671

Location

United States

Related Subject Headings

  • Synteny
  • Species Specificity
  • Sequence Analysis, DNA
  • Sequence Alignment
  • Proteins
  • Physical Chromosome Mapping
  • Molecular Sequence Data
  • Mice, Inbred Strains
  • Mice, Inbred DBA
  • Mice, Inbred A
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mural, R. J., Adams, M. D., Myers, E. W., Smith, H. O., Miklos, G. L. G., Wides, R., … Stephenson, L. D. (2002). A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science, 296(5573), 1661–1671. https://doi.org/10.1126/science.1069193
Mural, Richard J., Mark D. Adams, Eugene W. Myers, Hamilton O. Smith, George L Gabor Miklos, Ron Wides, Aaron Halpern, et al. “A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.Science 296, no. 5573 (May 31, 2002): 1661–71. https://doi.org/10.1126/science.1069193.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GLG, Wides R, et al. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science. 2002 May 31;296(5573):1661–71.
Mural, Richard J., et al. “A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.Science, vol. 296, no. 5573, May 2002, pp. 1661–71. Pubmed, doi:10.1126/science.1069193.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GLG, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji R-R, Gu Z, Wang Z-Y, Zhong F, Xiao C, Chiang C-C, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An H-J, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen Y-H, Cheng M-L, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers Y-HC, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science. 2002 May 31;296(5573):1661–1671.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

May 31, 2002

Volume

296

Issue

5573

Start / End Page

1661 / 1671

Location

United States

Related Subject Headings

  • Synteny
  • Species Specificity
  • Sequence Analysis, DNA
  • Sequence Alignment
  • Proteins
  • Physical Chromosome Mapping
  • Molecular Sequence Data
  • Mice, Inbred Strains
  • Mice, Inbred DBA
  • Mice, Inbred A