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Improving brain function of pediatric acute lymphoblastic leukemia patients after induction chemotherapy, a pilot self-contrast study by fractional amplitude of low-frequency fluctuation.

Publication ,  Journal Article
Zou, D; Wen, F; Zeng, H; Mai, H; Yuan, X; Wang, L; Li, Y; Liu, L; Liu, S; Liu, G
Published in: J Clin Neurosci
August 2019

Our previous study revealed altered resting-stated brain function in children with acute lymphoblastic leukemia (ALL) on new-onset stage. To investigate the effects after induction chemotherapy, a pilot self-contrast study was conducted to compare the difference in resting-stated brain function between pre- and post-induction chemotherapy of ALL. Fractional amplitude of low-frequency fluctuation (fALFF) was employed for fMRI data analysis. Clinical and resting state functional magnetic resonance imaging (RS-fMRI) data of 14 new-onset pediatric ALL patients were collected before and after 3 months of induction chemotherapy. Fourteen age- and gender-matched healthy controls (HCs) were recruited for comparison. Before induction chemotherapy, fALFF values of ALL patients decreased globally, especially in the default mode network (DMN), left frontal lobe, left occipital lobe, and bilateral postcentral gyri as compared to HCs. After induction chemotherapy, fALFF values of ALL patients decreased significantly in the bilateral cuneus, left lingual and calcarine gyri, and left mid frontal gyrus. Paired-sample t-tests and self-contrast analysis showed fALFF increased in the left precuneus, bilateral cuneus, left occipital lobe, bilateral frontal gyri, and bilateral temporal lobes, whereas fALFF in the bilateral precuneus decreased in the ALL patients after induction, which suggests potential side-effects of the treatment. The alteration of fALFF values suggested that resting brain function was impaired before induction chemotherapy and mostly recovered after treatment. This study suggested that fALFF is a reliable and feasible tool in detecting spontaneous brain activity to monitor early neurocognitive impairments in pediatric ALL to better understand the underlying neurobiological mechanisms of chemotherapy on the brain.

Duke Scholars

Published In

J Clin Neurosci

DOI

EISSN

1532-2653

Publication Date

August 2019

Volume

66

Start / End Page

149 / 155

Location

Scotland

Related Subject Headings

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Pilot Projects
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Induction Chemotherapy
  • Humans
  • Female
  • Child
  • Brain Mapping
 

Citation

APA
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ICMJE
MLA
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Zou, D., Wen, F., Zeng, H., Mai, H., Yuan, X., Wang, L., … Liu, G. (2019). Improving brain function of pediatric acute lymphoblastic leukemia patients after induction chemotherapy, a pilot self-contrast study by fractional amplitude of low-frequency fluctuation. J Clin Neurosci, 66, 149–155. https://doi.org/10.1016/j.jocn.2019.04.033
Zou, Dongfang, Feiqiu Wen, Hongwu Zeng, Huirong Mai, Xiuli Yuan, Lihong Wang, Yue Li, Liwei Liu, Sixi Liu, and Guosheng Liu. “Improving brain function of pediatric acute lymphoblastic leukemia patients after induction chemotherapy, a pilot self-contrast study by fractional amplitude of low-frequency fluctuation.J Clin Neurosci 66 (August 2019): 149–55. https://doi.org/10.1016/j.jocn.2019.04.033.
Journal cover image

Published In

J Clin Neurosci

DOI

EISSN

1532-2653

Publication Date

August 2019

Volume

66

Start / End Page

149 / 155

Location

Scotland

Related Subject Headings

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Pilot Projects
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Induction Chemotherapy
  • Humans
  • Female
  • Child
  • Brain Mapping