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Altered brain function in new onset childhood acute lymphoblastic leukemia before chemotherapy: A resting-state fMRI study.

Publication ,  Journal Article
Hu, Z; Zou, D; Mai, H; Yuan, X; Wang, L; Li, Y; Liao, J; Liu, L; Liu, G; Zeng, H; Wen, F
Published in: Brain Dev
October 2017

OBJECTIVE: Cognitive impairments had been reported in childhood acute lymphoblastic leukemia, what caused the impairments needed to be demonstrated, chemotherapy-related or the disease itself. The primary aim of this exploratory investigation was to determine if there were changes in brain function of children with acute lymphoblastic leukemia before chemotherapy. METHODS: In this study, we advanced a measure named regional homogeneity to evaluate the resting-state brain activities, intelligence quotient test was performed at same time. Using regional homogeneity, we first investigated the resting state brain function in patients with new onset childhood acute lymphoblastic leukemia before chemotherapy, healthy children as control. RESULTS: The decreased ReHo values were mainly founded in the default mode network and left frontal lobe, bilateral inferior parietal lobule, bilateral temporal lobe, bilateral occipital lobe, precentral gyrus, bilateral cerebellum in the newly diagnosed acute lymphoblastic leukemia patients compared with the healthy control. While in contrast, increased ReHo values were mainly shown in the right frontal lobe (language area), superior frontal gyrus-R, middle frontal gyrus-R and inferior parietal lobule-R for acute lymphoblastic leukemia patients group. There were no significant differences for intelligence quotient measurements between the acute lymphoblastic leukemia patient group and the healthy control in performance intelligence quotient, verbal intelligence quotient, total intelligence quotient. CONCLUSION: The altered brain functions are associated with cognitive change and language, it is suggested that there may be cognition impairment before the chemotherapy. Regional homogeneity by functional magnetic resonance image is a sensitive way for early detection on brain damage in childhood acute lymphoblastic leukemia.

Duke Scholars

Published In

Brain Dev

DOI

EISSN

1872-7131

Publication Date

October 2017

Volume

39

Issue

9

Start / End Page

743 / 750

Location

Netherlands

Related Subject Headings

  • Rest
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oxygen
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Intelligence
  • Infant
  • Image Processing, Computer-Assisted
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hu, Z., Zou, D., Mai, H., Yuan, X., Wang, L., Li, Y., … Wen, F. (2017). Altered brain function in new onset childhood acute lymphoblastic leukemia before chemotherapy: A resting-state fMRI study. Brain Dev, 39(9), 743–750. https://doi.org/10.1016/j.braindev.2017.04.014
Hu, Zhanqi, Dongfang Zou, Huirong Mai, Xiuli Yuan, Lihong Wang, Yue Li, Jianxiang Liao, et al. “Altered brain function in new onset childhood acute lymphoblastic leukemia before chemotherapy: A resting-state fMRI study.Brain Dev 39, no. 9 (October 2017): 743–50. https://doi.org/10.1016/j.braindev.2017.04.014.
Hu Z, Zou D, Mai H, Yuan X, Wang L, Li Y, et al. Altered brain function in new onset childhood acute lymphoblastic leukemia before chemotherapy: A resting-state fMRI study. Brain Dev. 2017 Oct;39(9):743–50.
Hu, Zhanqi, et al. “Altered brain function in new onset childhood acute lymphoblastic leukemia before chemotherapy: A resting-state fMRI study.Brain Dev, vol. 39, no. 9, Oct. 2017, pp. 743–50. Pubmed, doi:10.1016/j.braindev.2017.04.014.
Hu Z, Zou D, Mai H, Yuan X, Wang L, Li Y, Liao J, Liu L, Liu G, Zeng H, Wen F. Altered brain function in new onset childhood acute lymphoblastic leukemia before chemotherapy: A resting-state fMRI study. Brain Dev. 2017 Oct;39(9):743–750.
Journal cover image

Published In

Brain Dev

DOI

EISSN

1872-7131

Publication Date

October 2017

Volume

39

Issue

9

Start / End Page

743 / 750

Location

Netherlands

Related Subject Headings

  • Rest
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oxygen
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Intelligence
  • Infant
  • Image Processing, Computer-Assisted
  • Humans