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[Brain injury after induction chemotherapy in children with acute lymphoblastic leukemia].

Publication ,  Journal Article
Zou, D-F; Zeng, H-W; Yu, J; Mai, H-R; Yuan, X-L; Wang, L-H; Liao, J-X; Wen, F-Q
Published in: Zhongguo Dang Dai Er Ke Za Zhi
March 2016

OBJECTIVE: To investigate the changes in brain injury after the induction chemotherapy in children with acute lymphoblastic leukemia (ALL) by cranial MRI. METHODS: The clinical data and cranial MRI results of 62 children with ALL who were hospitalized from March 2014 to June 2015 were analyzed retrospectively. RESULTS: Before chemotherapy, MRI showed bone marrow infiltration of the skull in 33 patients (53%); the children with WBC<20×10(9)/Lhad a significantly lower incidence rate of bone marrow infiltration of the skull than those with WBC≥20×10(9)/L (16 patients/42% vs 17 patients/71%; P<0.05), and the high-risk group had a significantly higher incidence rate of bone marrow infiltration of the skull than the non-high-risk group (71% vs 44%; P<0.05). Before chemotherapy, there were 4 cases (7%) of brain atrophy, and 2 cases (3%) of abnormal signals in the sensory conduction bundle. MRI reexamination in 28 patients after 3 months of chemotherapy showed 3 new cases (11%) of brain atrophy and 1 aggravated case of brain atrophy. CONCLUSIONS: The children with ALL have bone marrow infiltration of the skull, brain atrophy, and abnormal signals in the sensory conduction bundle before chemotherapy, especially bone marrow infiltration of the skull, and some changes in brain injury disappear after treatment.

Duke Scholars

Published In

Zhongguo Dang Dai Er Ke Za Zhi

DOI

ISSN

1008-8830

Publication Date

March 2016

Volume

18

Issue

3

Start / End Page

254 / 258

Location

China

Related Subject Headings

  • Skull
  • Retrospective Studies
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Pediatrics
  • Male
  • Magnetic Resonance Imaging
  • Infant
  • Induction Chemotherapy
  • Humans
  • Female
 

Citation

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Zou, D.-F., Zeng, H.-W., Yu, J., Mai, H.-R., Yuan, X.-L., Wang, L.-H., … Wen, F.-Q. (2016). [Brain injury after induction chemotherapy in children with acute lymphoblastic leukemia]. Zhongguo Dang Dai Er Ke Za Zhi, 18(3), 254–258. https://doi.org/10.7499/j.issn.1008-8830.2016.03.013
Zou, Dong-Fang, Hong-Wu Zeng, Jie Yu, Hui-Rong Mai, Xiu-Li Yuan, Li-Hong Wang, Jian-Xiang Liao, and Fei-Qiu Wen. “[Brain injury after induction chemotherapy in children with acute lymphoblastic leukemia].Zhongguo Dang Dai Er Ke Za Zhi 18, no. 3 (March 2016): 254–58. https://doi.org/10.7499/j.issn.1008-8830.2016.03.013.
Zou D-F, Zeng H-W, Yu J, Mai H-R, Yuan X-L, Wang L-H, et al. [Brain injury after induction chemotherapy in children with acute lymphoblastic leukemia]. Zhongguo Dang Dai Er Ke Za Zhi. 2016 Mar;18(3):254–8.
Zou, Dong-Fang, et al. “[Brain injury after induction chemotherapy in children with acute lymphoblastic leukemia].Zhongguo Dang Dai Er Ke Za Zhi, vol. 18, no. 3, Mar. 2016, pp. 254–58. Pubmed, doi:10.7499/j.issn.1008-8830.2016.03.013.
Zou D-F, Zeng H-W, Yu J, Mai H-R, Yuan X-L, Wang L-H, Liao J-X, Wen F-Q. [Brain injury after induction chemotherapy in children with acute lymphoblastic leukemia]. Zhongguo Dang Dai Er Ke Za Zhi. 2016 Mar;18(3):254–258.

Published In

Zhongguo Dang Dai Er Ke Za Zhi

DOI

ISSN

1008-8830

Publication Date

March 2016

Volume

18

Issue

3

Start / End Page

254 / 258

Location

China

Related Subject Headings

  • Skull
  • Retrospective Studies
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Pediatrics
  • Male
  • Magnetic Resonance Imaging
  • Infant
  • Induction Chemotherapy
  • Humans
  • Female