Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response.
Publication
, Journal Article
Zhang, X; Markovic-Plese, S
Published in: Immunol Res
2008
Statins' recently discovered anti-inflammatory effects place them at the forefront of the new therapies for chronic inflammatory and autoimmune diseases. Our recent study demonstrated that simvastatin exerts an independent immunomodulatory effect on the human monocytes and CD4+ cells. In addition to the statin-mediated effect on the monocyte cytokine production, which regulates Th17 cell differentiation, simvastatin directly inhibits IL-17 production in CD4+ cells, which may collectively inhibit the autoimmune response in multiple sclerosis (MS), a central nervous system (CNS) inflammatory demyelinating disease.
Duke Scholars
Published In
Immunol Res
DOI
ISSN
0257-277X
Publication Date
2008
Volume
41
Issue
3
Start / End Page
165 / 174
Location
United States
Related Subject Headings
- Th2 Cells
- Th1 Cells
- Simvastatin
- Multiple Sclerosis
- Monocytes
- Membrane Microdomains
- Interleukin-17
- Immunology
- Immunologic Factors
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhang, X., & Markovic-Plese, S. (2008). Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response. Immunol Res, 41(3), 165–174. https://doi.org/10.1007/s12026-008-8019-z
Zhang, Xin, and Silva Markovic-Plese. “Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response.” Immunol Res 41, no. 3 (2008): 165–74. https://doi.org/10.1007/s12026-008-8019-z.
Zhang X, Markovic-Plese S. Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response. Immunol Res. 2008;41(3):165–74.
Zhang, Xin, and Silva Markovic-Plese. “Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response.” Immunol Res, vol. 41, no. 3, 2008, pp. 165–74. Pubmed, doi:10.1007/s12026-008-8019-z.
Zhang X, Markovic-Plese S. Statins' immunomodulatory potential against Th17 cell-mediated autoimmune response. Immunol Res. 2008;41(3):165–174.
Published In
Immunol Res
DOI
ISSN
0257-277X
Publication Date
2008
Volume
41
Issue
3
Start / End Page
165 / 174
Location
United States
Related Subject Headings
- Th2 Cells
- Th1 Cells
- Simvastatin
- Multiple Sclerosis
- Monocytes
- Membrane Microdomains
- Interleukin-17
- Immunology
- Immunologic Factors
- Hydroxymethylglutaryl-CoA Reductase Inhibitors