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Familial pancreatic cancer.

Publication ,  Journal Article
Shi, C; Hruban, RH; Klein, AP
Published in: Arch Pathol Lab Med
March 2009

CONTEXT: Approximately 5% to 10% of individuals with pancreatic cancer report a history of pancreatic cancer in a close family member. In addition, several known genetic syndromes, such as familial breast cancer (BRCA2), the Peutz-Jeghers syndrome, and the familial atypical multiple mole melanoma syndrome, have been shown to be associated with an increased risk of pancreatic cancer. The known genes associated with these conditions can explain only a portion of the clustering of pancreatic cancer in families, and research to identify additional susceptibility genes is ongoing. OBJECTIVE: To provide an understanding of familial pancreatic cancer and the pathology of familial exocrine pancreatic cancers. DATA SOURCES: Published literature on familial aggregation of pancreatic cancer and familial exocrine pancreatic tumors. CONCLUSIONS: Even in the absence of predictive genetic testing, the collection of a careful, detailed family history is an important step in the management of all patients with pancreatic cancer. While most pancreatic cancers that arise in patients with a family history are ductal adenocarcinomas, certain subtypes of pancreatic cancer have been associated with familial syndromes. Therefore, the histologic appearance of the pancreatic cancer itself, and/or the presence and appearance of precancerous changes in the pancreas, may increase the clinical index of suspicion for a genetic syndrome.

Duke Scholars

Published In

Arch Pathol Lab Med

DOI

EISSN

1543-2165

Publication Date

March 2009

Volume

133

Issue

3

Start / End Page

365 / 374

Location

United States

Related Subject Headings

  • Syndrome
  • Prognosis
  • Pathology
  • Pancreatic Neoplasms
  • Neoplasms, Glandular and Epithelial
  • Humans
  • Genetic Predisposition to Disease
  • Adenocarcinoma
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Shi, C., Hruban, R. H., & Klein, A. P. (2009). Familial pancreatic cancer. Arch Pathol Lab Med, 133(3), 365–374. https://doi.org/10.5858/133.3.365
Shi, Chanjuan, Ralph H. Hruban, and Alison P. Klein. “Familial pancreatic cancer.Arch Pathol Lab Med 133, no. 3 (March 2009): 365–74. https://doi.org/10.5858/133.3.365.
Shi C, Hruban RH, Klein AP. Familial pancreatic cancer. Arch Pathol Lab Med. 2009 Mar;133(3):365–74.
Shi, Chanjuan, et al. “Familial pancreatic cancer.Arch Pathol Lab Med, vol. 133, no. 3, Mar. 2009, pp. 365–74. Pubmed, doi:10.5858/133.3.365.
Shi C, Hruban RH, Klein AP. Familial pancreatic cancer. Arch Pathol Lab Med. 2009 Mar;133(3):365–374.

Published In

Arch Pathol Lab Med

DOI

EISSN

1543-2165

Publication Date

March 2009

Volume

133

Issue

3

Start / End Page

365 / 374

Location

United States

Related Subject Headings

  • Syndrome
  • Prognosis
  • Pathology
  • Pancreatic Neoplasms
  • Neoplasms, Glandular and Epithelial
  • Humans
  • Genetic Predisposition to Disease
  • Adenocarcinoma
  • 3202 Clinical sciences
  • 1103 Clinical Sciences