DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
Pancreatic neuroendocrine tumors (PanNETs) are a rare but clinically important form of pancreatic neoplasia. To explore the genetic basis of PanNETs, we determined the exomic sequences of 10 nonfamilial PanNETs and then screened the most commonly mutated genes in 58 additional PanNETs. The most frequently mutated genes specify proteins implicated in chromatin remodeling: 44% of the tumors had somatic inactivating mutations in MEN1, which encodes menin, a component of a histone methyltransferase complex, and 43% had mutations in genes encoding either of the two subunits of a transcription/chromatin remodeling complex consisting of DAXX (death-domain-associated protein) and ATRX (α thalassemia/mental retardation syndrome X-linked). Clinically, mutations in the MEN1 and DAXX/ATRX genes were associated with better prognosis. We also found mutations in genes in the mTOR (mammalian target of rapamycin) pathway in 14% of the tumors, a finding that could potentially be used to stratify patients for treatment with mTOR inhibitors.
Duke Scholars
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Related Subject Headings
- X-linked Nuclear Protein
- Tumor Suppressor Proteins
- Tuberous Sclerosis Complex 2 Protein
- TOR Serine-Threonine Kinases
- Signal Transduction
- Sequence Analysis, DNA
- Proto-Oncogene Proteins
- Prognosis
- Phosphatidylinositol 3-Kinases
- Pancreatic Neoplasms
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- X-linked Nuclear Protein
- Tumor Suppressor Proteins
- Tuberous Sclerosis Complex 2 Protein
- TOR Serine-Threonine Kinases
- Signal Transduction
- Sequence Analysis, DNA
- Proto-Oncogene Proteins
- Prognosis
- Phosphatidylinositol 3-Kinases
- Pancreatic Neoplasms