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The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting.

Publication ,  Journal Article
Kern, SE; Shi, C; Hruban, RH
Published in: J Pathol
January 2011

The directions of differentiation and the molecular features of ductal pancreatic cancer have by now been explored in reasonable detail. Already, diagnoses and therapeutic strategies benefit from observations distinguishing the major variant types of pancreatic cancer and the differing stages of disease at presentation. Additionally, individual patients differ within each variant type. In certain high-risk groups, this permits focused screening efforts. The tumorigenic influences that characterize individual patients are increasingly considered appropriate in defining clinical treatment plans. As a result, multiple variables affect success when individualizing screening or therapy. These competing variables often limit the potential for success: some variables dominate and should receive greater consideration than others. Simplistic expectations, often falsely optimistic, for individualized care may fail to 'pan out' in the real world. The development of individualized care will be efficient only when the full complexity of the disease is embraced.

Duke Scholars

Published In

J Pathol

DOI

EISSN

1096-9896

Publication Date

January 2011

Volume

223

Issue

2

Start / End Page

295 / 306

Location

England

Related Subject Headings

  • Precancerous Conditions
  • Pathology
  • Pancreatic Neoplasms
  • Mutation
  • Molecular Targeted Therapy
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Carcinoma, Pancreatic Ductal
  • Antineoplastic Agents
  • 3211 Oncology and carcinogenesis
 

Citation

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ICMJE
MLA
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Kern, S. E., Shi, C., & Hruban, R. H. (2011). The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting. J Pathol, 223(2), 295–306. https://doi.org/10.1002/path.2813
Kern, Scott E., Chanjuan Shi, and Ralph H. Hruban. “The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting.J Pathol 223, no. 2 (January 2011): 295–306. https://doi.org/10.1002/path.2813.
Kern, Scott E., et al. “The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting.J Pathol, vol. 223, no. 2, Jan. 2011, pp. 295–306. Pubmed, doi:10.1002/path.2813.
Journal cover image

Published In

J Pathol

DOI

EISSN

1096-9896

Publication Date

January 2011

Volume

223

Issue

2

Start / End Page

295 / 306

Location

England

Related Subject Headings

  • Precancerous Conditions
  • Pathology
  • Pancreatic Neoplasms
  • Mutation
  • Molecular Targeted Therapy
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Carcinoma, Pancreatic Ductal
  • Antineoplastic Agents
  • 3211 Oncology and carcinogenesis