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Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients.

Publication ,  Journal Article
Shi, C; Klein, AP; Goggins, M; Maitra, A; Canto, M; Ali, S; Schulick, R; Palmisano, E; Hruban, RH
Published in: Clin Cancer Res
December 15, 2009

PURPOSE: Histologic findings in 51 pancreata resected from patients with a strong family history of pancreatic cancer were compared with the findings in 40 pancreata resected from patients with sporadic pancreatic cancer. None of the patients in the familial group had a known inherited syndrome other than familial pancreatic cancer. EXPERIMENTAL DESIGN: Precursor lesions, including pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and incipient IPMN, were quantified. Invasive cancers were classified using established histologic criteria. RESULTS: The individual precursor lesions identified in both groups were histologically similar. Precursor lesions were more common in the familial cases than in the sporadic cases. The relative rate of PanINs per square centimeter was 2.75-fold higher (95% confidence interval, 2.05-3.70; adjusted for age) in familial compared with sporadic cases. PanIN-3 lesions were more common in familial versus sporadic pancreatic cancer patients (relative rate, 4.20; 95% confidence interval, 2.22-7.93; adjusted for age). High-grade incipient IPMNs were only observed in the familial cases. Nine of the 51 (18%) familial pancreatic cancers and 4 of the 40 (10%) sporadic cancers arose in association with an IPMN. No significant differences were found in the types of invasive cancers. CONCLUSIONS: Noninvasive precursor lesions are more common in patients with a strong family history of pancreatic cancer than in patients with sporadic disease, and precursor lesions are of a higher grade in patients with a strong family history of pancreatic cancer. These findings can form a basis for the design of screening tests for the early detection of pancreatic neoplasia. (Clin Cancer Res 2009;15(24):7737-43).

Duke Scholars

Published In

Clin Cancer Res

DOI

EISSN

1557-3265

Publication Date

December 15, 2009

Volume

15

Issue

24

Start / End Page

7737 / 7743

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shi, C., Klein, A. P., Goggins, M., Maitra, A., Canto, M., Ali, S., … Hruban, R. H. (2009). Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients. Clin Cancer Res, 15(24), 7737–7743. https://doi.org/10.1158/1078-0432.CCR-09-0004
Shi, Chanjuan, Alison P. Klein, Michael Goggins, Anirban Maitra, Marcia Canto, Syed Ali, Richard Schulick, Emily Palmisano, and Ralph H. Hruban. “Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients.Clin Cancer Res 15, no. 24 (December 15, 2009): 7737–43. https://doi.org/10.1158/1078-0432.CCR-09-0004.
Shi C, Klein AP, Goggins M, Maitra A, Canto M, Ali S, et al. Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients. Clin Cancer Res. 2009 Dec 15;15(24):7737–43.
Shi, Chanjuan, et al. “Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients.Clin Cancer Res, vol. 15, no. 24, Dec. 2009, pp. 7737–43. Pubmed, doi:10.1158/1078-0432.CCR-09-0004.
Shi C, Klein AP, Goggins M, Maitra A, Canto M, Ali S, Schulick R, Palmisano E, Hruban RH. Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients. Clin Cancer Res. 2009 Dec 15;15(24):7737–7743.

Published In

Clin Cancer Res

DOI

EISSN

1557-3265

Publication Date

December 15, 2009

Volume

15

Issue

24

Start / End Page

7737 / 7743

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis