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Molecular characterization of pancreatic neoplasms.

Publication ,  Journal Article
Shi, C; Daniels, JA; Hruban, RH
Published in: Adv Anat Pathol
July 2008

Molecular analyses of neoplasms of the pancreas, coupled with careful histopathologic examination has helped refine the classification of pancreatic neoplasia. A number of molecularly and histologically distinct subtypes of pancreatic neoplasms have been identified and, importantly, many of these subtypes have important clinical implications. For example, most of the solid-pseudopapillary neoplasms harbor mutations in the beta-catenin gene (CTNNB1), and, as a result, most solid-pseudopapillary neoplasms have an abnormal nuclear pattern of labeling with antibodies to the beta-catenin protein. Clinically, patients with a solid-pseudopapillary neoplasm have a much better prognosis than do patients with ductal adenocarcinoma of the pancreas. Therefore, the immunolabeling of a pancreatic biopsy for the beta-catenin protein can help identify patients with low-risk neoplasms. It is clear that the time is now ripe for a new modern classification of neoplasms of the pancreas; a classification that does not abandon gross and microscopic pathology, but which instead integrates molecular findings with gross, microscopic, and clinical findings.

Duke Scholars

Published In

Adv Anat Pathol

DOI

EISSN

1533-4031

Publication Date

July 2008

Volume

15

Issue

4

Start / End Page

185 / 195

Location

United States

Related Subject Headings

  • beta Catenin
  • Prognosis
  • Pathology
  • Pancreatic Neoplasms
  • Pancreas
  • Mutation
  • Humans
  • Genes, Neoplasm
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shi, C., Daniels, J. A., & Hruban, R. H. (2008). Molecular characterization of pancreatic neoplasms. Adv Anat Pathol, 15(4), 185–195. https://doi.org/10.1097/PAP.0b013e31817bf57d
Shi, Chanjuan, Jason A. Daniels, and Ralph H. Hruban. “Molecular characterization of pancreatic neoplasms.Adv Anat Pathol 15, no. 4 (July 2008): 185–95. https://doi.org/10.1097/PAP.0b013e31817bf57d.
Shi C, Daniels JA, Hruban RH. Molecular characterization of pancreatic neoplasms. Adv Anat Pathol. 2008 Jul;15(4):185–95.
Shi, Chanjuan, et al. “Molecular characterization of pancreatic neoplasms.Adv Anat Pathol, vol. 15, no. 4, July 2008, pp. 185–95. Pubmed, doi:10.1097/PAP.0b013e31817bf57d.
Shi C, Daniels JA, Hruban RH. Molecular characterization of pancreatic neoplasms. Adv Anat Pathol. 2008 Jul;15(4):185–195.

Published In

Adv Anat Pathol

DOI

EISSN

1533-4031

Publication Date

July 2008

Volume

15

Issue

4

Start / End Page

185 / 195

Location

United States

Related Subject Headings

  • beta Catenin
  • Prognosis
  • Pathology
  • Pancreatic Neoplasms
  • Pancreas
  • Mutation
  • Humans
  • Genes, Neoplasm
  • 3202 Clinical sciences
  • 1103 Clinical Sciences