Mucosal Vaccines
Innate Immunity based Mucosal Modulators and Adjuvants
Publication
, Chapter
Johnson-Weaver, B; Abraham, S; Staats, H
2020
The development of mucosally administered vaccines remains a goal of many researchers who desire to develop a needle-free method of immunization that can induce antigen-specific immune responses in both systemic and mucosal tissues. The coadministration of adjuvants is often required to maximize the induction of protective immunity following mucosal vaccination, especially when subunit immunogens are used. A major class of mucosal vaccine adjuvants and modulators includes substances that can activate the innate immune system. Innate immune system activators that exhibit mucosal vaccine adjuvant and modulator activity will be discussed, including proinflammatory cytokines, nanoemulsions, mast cell activators, and toll-like receptor ligands.
Duke Scholars
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DOI
ISBN
978-0-12-811924-2
Publication Date
2020
Start / End Page
167 / 183
Publisher
Academic Press
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Johnson-Weaver, B., Abraham, S., & Staats, H. (2020). Innate Immunity based Mucosal Modulators and Adjuvants. In H. Kiyono & D. Pascual (Eds.), Mucosal Vaccines (pp. 167–183). Academic Press. https://doi.org/10.1016/C2016-0-00017-7
Johnson-Weaver, Brandi, Soman Abraham, and Herman Staats. “Innate Immunity based Mucosal Modulators and Adjuvants.” In Mucosal Vaccines, edited by Hiroshi Kiyono and David Pascual, 167–83. Academic Press, 2020. https://doi.org/10.1016/C2016-0-00017-7.
Johnson-Weaver B, Abraham S, Staats H. Innate Immunity based Mucosal Modulators and Adjuvants. In: Kiyono H, Pascual D, editors. Mucosal Vaccines. Academic Press; 2020. p. 167–83.
Johnson-Weaver, Brandi, et al. “Innate Immunity based Mucosal Modulators and Adjuvants.” Mucosal Vaccines, edited by Hiroshi Kiyono and David Pascual, Academic Press, 2020, pp. 167–83. Manual, doi:10.1016/C2016-0-00017-7.
Johnson-Weaver B, Abraham S, Staats H. Innate Immunity based Mucosal Modulators and Adjuvants. In: Kiyono H, Pascual D, editors. Mucosal Vaccines. Academic Press; 2020. p. 167–183.
DOI
ISBN
978-0-12-811924-2
Publication Date
2020
Start / End Page
167 / 183
Publisher
Academic Press