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HIV Transmission Patterns Among Immigrant Latinos Illuminated by the Integration of Phylogenetic and Migration Data.

Publication ,  Journal Article
Dennis, AM; Hué, S; Pasquale, D; Napravnik, S; Sebastian, J; Miller, WC; Eron, JJ
Published in: AIDS Res Hum Retroviruses
October 2015

Latinos represent a growing proportion of HIV cases in North Carolina (NC). Understanding how immigrants are involved in local HIV transmission is important to guide interventions. We used phylogenetics to characterize Latino involvement in local HIV transmission chains. Transmission clusters were identified from maximum-likelihood phylogenies constructed with HIV pol sequences from 177 Latinos and 1,496 non-Latinos receiving care in NC. Highly supported clusters involving one or more Latinos were characterized. Migration data were obtained from interviews and chart review. Factors associated with cluster membership were identified using log-binomial regression. Most Latinos were male (76%), immigrants (83%), and had HIV-1B (99%). Immigrants were more likely to report heterosexual risk (67% vs. 23%) than U.S.-born Latinos (p < 0.01). We identified 32 clusters that included one or more Latinos; these involved 53 Latinos (30%) and 41 non-Latinos. Immigrant and U.S.-born Latinos were equally likely to be in clusters, but immigrants were more likely to be in clusters with another Latino (78% vs. 29%; p = 0.02). Cluster composition by ethnicity and risk behavior varied by cluster size; larger clusters contained fewer immigrants and more men who have sex with men (MSM). Factors associated with immigrant membership in local transmission clusters included age <30 years [RR 2.34 (95% CI 1.47-3.73)], Mexican origin [RR 2.55 (95% CI 1.29-6.88)], and residing in the United States longer before diagnosis [RR 1.53 (95% CI 1.09-2.15), per 10 years]. While some Latinos immigrate with HIV infection, many immigrants are involved in transmission networks after arrival, particularly MSM. HIV testing and prevention interventions must consider this heterogeneity and may be better targeted by integrating phylogenetic analyses.

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Published In

AIDS Res Hum Retroviruses

DOI

EISSN

1931-8405

Publication Date

October 2015

Volume

31

Issue

10

Start / End Page

973 / 980

Location

United States

Related Subject Headings

  • pol Gene Products, Human Immunodeficiency Virus
  • Young Adult
  • Virology
  • United States
  • Sexual Behavior
  • Sequence Analysis, DNA
  • Risk-Taking
  • Phylogeny
  • Molecular Epidemiology
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Dennis, A. M., Hué, S., Pasquale, D., Napravnik, S., Sebastian, J., Miller, W. C., & Eron, J. J. (2015). HIV Transmission Patterns Among Immigrant Latinos Illuminated by the Integration of Phylogenetic and Migration Data. AIDS Res Hum Retroviruses, 31(10), 973–980. https://doi.org/10.1089/AID.2015.0089
Dennis, Ann M., Stéphane Hué, Dana Pasquale, Sonia Napravnik, Joseph Sebastian, William C. Miller, and Joseph J. Eron. “HIV Transmission Patterns Among Immigrant Latinos Illuminated by the Integration of Phylogenetic and Migration Data.AIDS Res Hum Retroviruses 31, no. 10 (October 2015): 973–80. https://doi.org/10.1089/AID.2015.0089.
Dennis AM, Hué S, Pasquale D, Napravnik S, Sebastian J, Miller WC, et al. HIV Transmission Patterns Among Immigrant Latinos Illuminated by the Integration of Phylogenetic and Migration Data. AIDS Res Hum Retroviruses. 2015 Oct;31(10):973–80.
Dennis, Ann M., et al. “HIV Transmission Patterns Among Immigrant Latinos Illuminated by the Integration of Phylogenetic and Migration Data.AIDS Res Hum Retroviruses, vol. 31, no. 10, Oct. 2015, pp. 973–80. Pubmed, doi:10.1089/AID.2015.0089.
Dennis AM, Hué S, Pasquale D, Napravnik S, Sebastian J, Miller WC, Eron JJ. HIV Transmission Patterns Among Immigrant Latinos Illuminated by the Integration of Phylogenetic and Migration Data. AIDS Res Hum Retroviruses. 2015 Oct;31(10):973–980.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

EISSN

1931-8405

Publication Date

October 2015

Volume

31

Issue

10

Start / End Page

973 / 980

Location

United States

Related Subject Headings

  • pol Gene Products, Human Immunodeficiency Virus
  • Young Adult
  • Virology
  • United States
  • Sexual Behavior
  • Sequence Analysis, DNA
  • Risk-Taking
  • Phylogeny
  • Molecular Epidemiology
  • Male