Regulation of γδ T Cell Effector Diversification in the Thymus.
γδ T cells are the first T cell lineage to develop in the thymus and take up residence in a wide variety of tissues where they can provide fast, innate-like sources of effector cytokines for barrier defense. In contrast to conventional αβ T cells that egress the thymus as naïve cells, γδ T cells can be programmed for effector function during development in the thymus. Understanding the molecular mechanisms that determine γδ T cell effector fate is of great interest due to the wide-spread tissue distribution of γδ T cells and their roles in pathogen clearance, immunosurveillance, cancer, and autoimmune diseases. In this review, we will integrate the current understanding of the role of the T cell receptor, environmental signals, and transcription factor networks in controlling mouse innate-like γδ T cell effector commitment.
Duke Scholars
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Related Subject Headings
- Thymus Gland
- Signal Transduction
- Receptors, Antigen, T-Cell, gamma-delta
- Mice
- Intraepithelial Lymphocytes
- Immunity, Innate
- Gene Regulatory Networks
- Cytokines
- Cell Lineage
- Cell Differentiation
Citation
Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Thymus Gland
- Signal Transduction
- Receptors, Antigen, T-Cell, gamma-delta
- Mice
- Intraepithelial Lymphocytes
- Immunity, Innate
- Gene Regulatory Networks
- Cytokines
- Cell Lineage
- Cell Differentiation