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Child Neurology: A young child with an undiagnosed case of dystonia responsive to l-dopa.

Publication ,  Journal Article
Trau, SP; Gallentine, WB; Mikati, MA
Published in: Neurology
February 18, 2020

Childhood-onset dystonias are a heterogeneously diverse group. There exists a specific set of dystonias that respond profoundly well to low doses of l-dopa (dopa-responsive dystonia [DRD]). Classical DRD is caused by deficiency of GTP cyclohydrolase 1 or tyrosine hydroxylase, but other conditions can cause dystonias that are partially responsive to dopamine. The idea of a diagnostic therapeutic trial with l-dopa for children who present with dystonia has been around for decades and is frequently advocated for; however, l-dopa trials are not without risk.

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Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

February 18, 2020

Volume

94

Issue

7

Start / End Page

326 / 328

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Male
  • Levodopa
  • Humans
  • Dystonic Disorders
  • Drug Combinations
  • Diagnosis, Differential
  • Child, Preschool
  • Carbidopa
  • Anti-Dyskinesia Agents
 

Citation

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ICMJE
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Trau, S. P., Gallentine, W. B., & Mikati, M. A. (2020). Child Neurology: A young child with an undiagnosed case of dystonia responsive to l-dopa. Neurology, 94(7), 326–328. https://doi.org/10.1212/WNL.0000000000008963
Trau, Steven P., William B. Gallentine, and Mohamad A. Mikati. “Child Neurology: A young child with an undiagnosed case of dystonia responsive to l-dopa.Neurology 94, no. 7 (February 18, 2020): 326–28. https://doi.org/10.1212/WNL.0000000000008963.
Trau SP, Gallentine WB, Mikati MA. Child Neurology: A young child with an undiagnosed case of dystonia responsive to l-dopa. Neurology. 2020 Feb 18;94(7):326–8.
Trau, Steven P., et al. “Child Neurology: A young child with an undiagnosed case of dystonia responsive to l-dopa.Neurology, vol. 94, no. 7, Feb. 2020, pp. 326–28. Pubmed, doi:10.1212/WNL.0000000000008963.
Trau SP, Gallentine WB, Mikati MA. Child Neurology: A young child with an undiagnosed case of dystonia responsive to l-dopa. Neurology. 2020 Feb 18;94(7):326–328.

Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

February 18, 2020

Volume

94

Issue

7

Start / End Page

326 / 328

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Male
  • Levodopa
  • Humans
  • Dystonic Disorders
  • Drug Combinations
  • Diagnosis, Differential
  • Child, Preschool
  • Carbidopa
  • Anti-Dyskinesia Agents