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Vascular Cellular Adhesion Molecule-1 (VCAM-1) and Memory Impairment in African-Americans after Small Vessel-Type Stroke.

Publication ,  Journal Article
El Husseini, N; Bushnell, C; Brown, CM; Attix, D; Rost, NS; Samsa, GP; Colton, CA; Goldstein, LB
Published in: J Stroke Cerebrovasc Dis
April 2020

BACKGROUND: African-Americans (AA) are 3 times more likely to have small-vessel-type ischemic strokes (SVS) than Whites. Small vessel strokes are associated with cognitive impairment, a relationship incompletely explained by white matter hyperintensity (WMH) burden. We examined whether inflammatory/endothelial dysfunction biomarkers are associated with cognition after SVS in AAs. METHODS: Biomarkers were obtained in 24 subjects (median age 56.5 years, 54% women, median 12 years education). Cognition was assessed more than 6 weeks poststroke using the memory composite score (MCS), which was generated using recall from the Hopkins Verbal Learning Test-II and Brief Visuospatial Memory Test-Revised. A semi-automated, volumetric protocol was used to quantify WMH volume (WMHv) on clinical MRI scans. Potential biomarkers including vascular cell adhesion molecule-1 (VCAM-1), interleukin-1 receptor antagonist, interleukin-6, interleukin-8, interleukin-10, interferon gamma, and thrombin-antithrombin (TAT) were log-transformed and correlated with MCS with adjustment for potential confounders. RESULTS: Among serum biomarkers, only VCAM-1-correlated with poorer memory based on the MCS (r = -.659; P = .0006). VCAM-1 (r = .554; P = .005) and age (r = .479; P = .018) correlated with WMHv; VCAM-1 was independently associated with MCS after adjustment for WMHv, age, and education (P = .023). CONCLUSIONS: The findings of this exploratory analysis suggest that endothelial dysfunction and inflammation as reflected by VCAM-1 levels may play a role in poststroke cognitive impairment. Additional studies are needed to validate this observation and to evaluate this relationship in non-AAs and with other stroke types and compare this finding to cognitive impairment in nonstroke populations.

Duke Scholars

Published In

J Stroke Cerebrovasc Dis

DOI

EISSN

1532-8511

Publication Date

April 2020

Volume

29

Issue

4

Start / End Page

104646

Location

United States

Related Subject Headings

  • Vascular Cell Adhesion Molecule-1
  • United States
  • Stroke
  • Risk Factors
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Middle Aged
  • Memory Disorders
  • Memory
  • Male
 

Citation

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El Husseini, N., Bushnell, C., Brown, C. M., Attix, D., Rost, N. S., Samsa, G. P., … Goldstein, L. B. (2020). Vascular Cellular Adhesion Molecule-1 (VCAM-1) and Memory Impairment in African-Americans after Small Vessel-Type Stroke. J Stroke Cerebrovasc Dis, 29(4), 104646. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104646
El Husseini, Nada, Cheryl Bushnell, Candice M. Brown, Deborah Attix, Natalia S. Rost, Gregory P. Samsa, Carol A. Colton, and Larry B. Goldstein. “Vascular Cellular Adhesion Molecule-1 (VCAM-1) and Memory Impairment in African-Americans after Small Vessel-Type Stroke.J Stroke Cerebrovasc Dis 29, no. 4 (April 2020): 104646. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104646.
El Husseini N, Bushnell C, Brown CM, Attix D, Rost NS, Samsa GP, et al. Vascular Cellular Adhesion Molecule-1 (VCAM-1) and Memory Impairment in African-Americans after Small Vessel-Type Stroke. J Stroke Cerebrovasc Dis. 2020 Apr;29(4):104646.
El Husseini, Nada, et al. “Vascular Cellular Adhesion Molecule-1 (VCAM-1) and Memory Impairment in African-Americans after Small Vessel-Type Stroke.J Stroke Cerebrovasc Dis, vol. 29, no. 4, Apr. 2020, p. 104646. Pubmed, doi:10.1016/j.jstrokecerebrovasdis.2020.104646.
El Husseini N, Bushnell C, Brown CM, Attix D, Rost NS, Samsa GP, Colton CA, Goldstein LB. Vascular Cellular Adhesion Molecule-1 (VCAM-1) and Memory Impairment in African-Americans after Small Vessel-Type Stroke. J Stroke Cerebrovasc Dis. 2020 Apr;29(4):104646.
Journal cover image

Published In

J Stroke Cerebrovasc Dis

DOI

EISSN

1532-8511

Publication Date

April 2020

Volume

29

Issue

4

Start / End Page

104646

Location

United States

Related Subject Headings

  • Vascular Cell Adhesion Molecule-1
  • United States
  • Stroke
  • Risk Factors
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Middle Aged
  • Memory Disorders
  • Memory
  • Male