Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.
Publication
, Journal Article
Durante, MA; Kurtenbach, S; Sargi, ZB; Harbour, JW; Choi, R; Kurtenbach, S; Goss, GM; Matsunami, H; Goldstein, BJ
Published in: Nat Neurosci
March 2020
The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans.
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Published In
Nat Neurosci
DOI
EISSN
1546-1726
Publication Date
March 2020
Volume
23
Issue
3
Start / End Page
323 / 326
Location
United States
Related Subject Headings
- Smell
- Single-Cell Analysis
- Sequence Analysis, RNA
- Olfactory Receptor Neurons
- Olfactory Mucosa
- Neurology & Neurosurgery
- Neurogenesis
- Neural Stem Cells
- Humans
- Aging
Citation
APA
Chicago
ICMJE
MLA
NLM
Durante, M. A., Kurtenbach, S., Sargi, Z. B., Harbour, J. W., Choi, R., Goss, G. M., … Goldstein, B. J. (2020). Single-cell analysis of olfactory neurogenesis and differentiation in adult humans. Nat Neurosci, 23(3), 323–326. https://doi.org/10.1038/s41593-020-0587-9
Durante, Michael A., Stefan Kurtenbach, Zoukaa B. Sargi, J William Harbour, Rhea Choi, Sarah Kurtenbach, Garrett M. Goss, Hiroaki Matsunami, and Bradley J. Goldstein. “Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.” Nat Neurosci 23, no. 3 (March 2020): 323–26. https://doi.org/10.1038/s41593-020-0587-9.
Durante MA, Kurtenbach S, Sargi ZB, Harbour JW, Choi R, Goss GM, et al. Single-cell analysis of olfactory neurogenesis and differentiation in adult humans. Nat Neurosci. 2020 Mar;23(3):323–6.
Durante, Michael A., et al. “Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.” Nat Neurosci, vol. 23, no. 3, Mar. 2020, pp. 323–26. Pubmed, doi:10.1038/s41593-020-0587-9.
Durante MA, Kurtenbach S, Sargi ZB, Harbour JW, Choi R, Goss GM, Matsunami H, Goldstein BJ. Single-cell analysis of olfactory neurogenesis and differentiation in adult humans. Nat Neurosci. 2020 Mar;23(3):323–326.
Published In
Nat Neurosci
DOI
EISSN
1546-1726
Publication Date
March 2020
Volume
23
Issue
3
Start / End Page
323 / 326
Location
United States
Related Subject Headings
- Smell
- Single-Cell Analysis
- Sequence Analysis, RNA
- Olfactory Receptor Neurons
- Olfactory Mucosa
- Neurology & Neurosurgery
- Neurogenesis
- Neural Stem Cells
- Humans
- Aging