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Regulation and Effects of FGF23 in Chronic Kidney Disease.

Publication ,  Book
Musgrove, J; Wolf, M
February 10, 2020

Chronic kidney disease (CKD) is a global health epidemic that accelerates cardiovascular disease, increases risk of infection, and causes anemia and bone disease, among other complications that collectively increase risk of premature death. Alterations in calcium and phosphate homeostasis have long been considered nontraditional risk factors for many of the most morbid outcomes of CKD. The discovery of fibroblast growth factor 23 (FGF23), which revolutionized the diagnosis and treatment of rare hereditary disorders of FGF23 excess that cause hypophosphatemic rickets, has also driven major paradigm shifts in our understanding of the pathophysiology and downstream end-organ complications of disordered mineral metabolism in CKD. As research of FGF23 in CKD has rapidly advanced, major new questions about its regulation and effects continuously emerge. These are promoting exciting innovations in laboratory, patient-oriented, and epidemiological research and stimulating clinical trials of new therapies and repurposing of existing ones to target FGF23.

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DOI

Publication Date

February 10, 2020

Volume

82

Start / End Page

365 / 390

Related Subject Headings

  • Renal Insufficiency, Chronic
  • Physiology
  • Humans
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Animals
  • 3208 Medical physiology
  • 3109 Zoology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

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Musgrove, J., & Wolf, M. (2020). Regulation and Effects of FGF23 in Chronic Kidney Disease. (Vol. 82, pp. 365–390). https://doi.org/10.1146/annurev-physiol-021119-034650
Musgrove, John, and Myles Wolf. Regulation and Effects of FGF23 in Chronic Kidney Disease. Vol. 82, 2020. https://doi.org/10.1146/annurev-physiol-021119-034650.
Musgrove, John, and Myles Wolf. Regulation and Effects of FGF23 in Chronic Kidney Disease. Vol. 82, 2020, pp. 365–90. Pubmed, doi:10.1146/annurev-physiol-021119-034650.
Musgrove J, Wolf M. Regulation and Effects of FGF23 in Chronic Kidney Disease. 2020. p. 365–390.

DOI

Publication Date

February 10, 2020

Volume

82

Start / End Page

365 / 390

Related Subject Headings

  • Renal Insufficiency, Chronic
  • Physiology
  • Humans
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Animals
  • 3208 Medical physiology
  • 3109 Zoology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences