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State of the Art: Toward Improving Outcomes of Lung and Liver Tumor Biopsies in Clinical Trials-A Multidisciplinary Approach.

Publication ,  Journal Article
Levy, EB; Fiel, MI; Hamilton, SR; Kleiner, DE; McCall, SJ; Schirmacher, P; Travis, W; Kuo, MD; Suh, RD; Tam, AL; Islam, SU; Ferry-Galow, K ...
Published in: J Clin Oncol
May 10, 2020

PURPOSE: National Cancer Institute (NCI)-sponsored clinical trial network studies frequently require biopsy specimens for pharmacodynamic and molecular biomarker analyses, including paired pre- and post-treatment samples. The purpose of this meeting of NCI-sponsored investigators was to identify local institutional standard procedures found to ensure quantitative and qualitative specimen adequacy. METHODS: NCI convened a conference on best biopsy practices, focusing on the clinical research community. Topics discussed were (1) criteria for specimen adequacy in the personalized medicine era, (2) team-based approaches to ensure specimen adequacy and quality control, and (3) risk considerations relevant to academic and community practitioners and their patients. RESULTS AND RECOMMENDATIONS: Key recommendations from the convened consensus panel included (1) establishment of infrastructure for multidisciplinary biopsy teams with a formalized information capture process, (2) maintenance of standard operating procedures with regular team review, (3) optimization of tissue collection and yield methodology, (4) incorporation of needle aspiration and other newer techniques, and (5) commitment of stakeholders to use of guideline documents to increase awareness of best biopsy practices, with the goal of universally improving tumor biopsy practices.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

May 10, 2020

Volume

38

Issue

14

Start / End Page

1633 / 1640

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Oncology & Carcinogenesis
  • National Cancer Institute (U.S.)
  • Lung Neoplasms
  • Liver Neoplasms
  • Humans
  • Clinical Trials as Topic
  • Biopsy
  • 3211 Oncology and carcinogenesis
 

Citation

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Levy, E. B., Fiel, M. I., Hamilton, S. R., Kleiner, D. E., McCall, S. J., Schirmacher, P., … Makhlouf, H. R. (2020). State of the Art: Toward Improving Outcomes of Lung and Liver Tumor Biopsies in Clinical Trials-A Multidisciplinary Approach. J Clin Oncol, 38(14), 1633–1640. https://doi.org/10.1200/JCO.19.02322
Levy, Elliot B., Maria I. Fiel, Stanley R. Hamilton, David E. Kleiner, Shannon J. McCall, Peter Schirmacher, William Travis, et al. “State of the Art: Toward Improving Outcomes of Lung and Liver Tumor Biopsies in Clinical Trials-A Multidisciplinary Approach.J Clin Oncol 38, no. 14 (May 10, 2020): 1633–40. https://doi.org/10.1200/JCO.19.02322.
Levy EB, Fiel MI, Hamilton SR, Kleiner DE, McCall SJ, Schirmacher P, et al. State of the Art: Toward Improving Outcomes of Lung and Liver Tumor Biopsies in Clinical Trials-A Multidisciplinary Approach. J Clin Oncol. 2020 May 10;38(14):1633–40.
Levy, Elliot B., et al. “State of the Art: Toward Improving Outcomes of Lung and Liver Tumor Biopsies in Clinical Trials-A Multidisciplinary Approach.J Clin Oncol, vol. 38, no. 14, May 2020, pp. 1633–40. Pubmed, doi:10.1200/JCO.19.02322.
Levy EB, Fiel MI, Hamilton SR, Kleiner DE, McCall SJ, Schirmacher P, Travis W, Kuo MD, Suh RD, Tam AL, Islam SU, Ferry-Galow K, Enos RA, Doroshow JH, Makhlouf HR. State of the Art: Toward Improving Outcomes of Lung and Liver Tumor Biopsies in Clinical Trials-A Multidisciplinary Approach. J Clin Oncol. 2020 May 10;38(14):1633–1640.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

May 10, 2020

Volume

38

Issue

14

Start / End Page

1633 / 1640

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Oncology & Carcinogenesis
  • National Cancer Institute (U.S.)
  • Lung Neoplasms
  • Liver Neoplasms
  • Humans
  • Clinical Trials as Topic
  • Biopsy
  • 3211 Oncology and carcinogenesis