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Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models.

Publication ,  Journal Article
Gutruf, P; Yin, RT; Lee, KB; Ausra, J; Brennan, JA; Qiao, Y; Xie, Z; Peralta, R; Talarico, O; Murillo, A; Chen, SW; Leshock, JP; Haney, CR ...
Published in: Nature communications
December 2019

Small animals support a wide range of pathological phenotypes and genotypes as versatile, affordable models for pathogenesis of cardiovascular diseases and for exploration of strategies in electrotherapy, gene therapy, and optogenetics. Pacing tools in such contexts are currently limited to tethered embodiments that constrain animal behaviors and experimental designs. Here, we introduce a highly miniaturized wireless energy-harvesting and digital communication electronics for thin, miniaturized pacing platforms weighing 110 mg with capabilities for subdermal implantation and tolerance to over 200,000 multiaxial cycles of strain without degradation in electrical or optical performance. Multimodal and multisite pacing in ex vivo and in vivo studies over many days demonstrate chronic stability and excellent biocompatibility. Optogenetic stimulation of cardiac cycles with in-animal control and induction of heart failure through chronic pacing serve as examples of modes of operation relevant to fundamental and applied cardiovascular research and biomedical technology.

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Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

December 2019

Volume

10

Issue

1

Start / End Page

5742

Related Subject Headings

  • Wireless Technology
  • Optogenetics
  • Miniaturization
  • Mice, Transgenic
  • Mice
  • Male
  • Isolated Heart Preparation
  • Humans
  • Heart Failure
  • Female
 

Citation

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MLA
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Gutruf, P., Yin, R. T., Lee, K. B., Ausra, J., Brennan, J. A., Qiao, Y., … Rogers, J. A. (2019). Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models. Nature Communications, 10(1), 5742. https://doi.org/10.1038/s41467-019-13637-w
Gutruf, Philipp, Rose T. Yin, K Benjamin Lee, Jokubas Ausra, Jaclyn A. Brennan, Yun Qiao, Zhaoqian Xie, et al. “Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models.Nature Communications 10, no. 1 (December 2019): 5742. https://doi.org/10.1038/s41467-019-13637-w.
Gutruf P, Yin RT, Lee KB, Ausra J, Brennan JA, Qiao Y, et al. Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models. Nature communications. 2019 Dec;10(1):5742.
Gutruf, Philipp, et al. “Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models.Nature Communications, vol. 10, no. 1, Dec. 2019, p. 5742. Epmc, doi:10.1038/s41467-019-13637-w.
Gutruf P, Yin RT, Lee KB, Ausra J, Brennan JA, Qiao Y, Xie Z, Peralta R, Talarico O, Murillo A, Chen SW, Leshock JP, Haney CR, Waters EA, Zhang C, Luan H, Huang Y, Trachiotis G, Efimov IR, Rogers JA. Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models. Nature communications. 2019 Dec;10(1):5742.

Published In

Nature communications

DOI

EISSN

2041-1723

ISSN

2041-1723

Publication Date

December 2019

Volume

10

Issue

1

Start / End Page

5742

Related Subject Headings

  • Wireless Technology
  • Optogenetics
  • Miniaturization
  • Mice, Transgenic
  • Mice
  • Male
  • Isolated Heart Preparation
  • Humans
  • Heart Failure
  • Female