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Future research prioritization in cardiac resynchronization therapy.

Publication ,  Journal Article
Fudim, M; Dalgaard, F; Al-Khatib, SM; J Friedman, D; Lallinger, K; Abraham, WT; Cleland, JGF; Curtis, AB; Gold, MR; Kutyifa, V; Linde, C ...
Published in: Am Heart J
May 2020

BACKGROUND: Although cardiac resynchronization therapy (CRT) is effective for some patients with heart failure and a reduced left ventricular ejection fraction (HFrEF), evidence gaps remain for key clinical and policy areas. The objective of the study was to review the data on the effects of CRT for patients with HFrEF receiving pharmacological therapy alone or pharmacological therapy and an implantable cardioverter-defibrillator (ICD) and then, informed by a diverse group of stakeholders, to identify evidence gaps, prioritize them, and develop a research plan. METHODS: Relevant studies were identified using PubMed and EMBASE and ongoing trials using clinicaltrials.gov. Forced-ranking prioritization method was applied by stakeholders to reach a consensus on the most important questions. Twenty-six stakeholders contributed to the expanded list of evidence gaps, including key investigators from existing randomized controlled trials and others representing different perspectives, including patients, the public, device manufacturers, and policymakers. RESULTS: Of the 18 top-tier evidence gaps, 8 were related to specific populations or subgroups of interest. Seven were related to the comparative effectiveness and safety of CRT interventions or comparators, and 3 were related to the association of CRT treatment with specific outcomes. The association of comorbidities with CRT effectiveness ranked highest, followed by questions about the effectiveness of CRT among patients with atrial fibrillation and the relationship between gender, QRS morphology and duration, and outcomes for patients either with CRT plus ICD or with ICD. CONCLUSIONS: Evidence gaps presented in this article highlight numerous, important clinical and policy questions for which there is inconclusive evidence on the role of CRT and provide a framework for future collaborative research.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2020

Volume

223

Start / End Page

48 / 58

Location

United States

Related Subject Headings

  • Stroke Volume
  • Research
  • Humans
  • Heart Failure
  • Forecasting
  • Cardiovascular System & Hematology
  • Cardiac Resynchronization Therapy
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
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Fudim, M., Dalgaard, F., Al-Khatib, S. M., J Friedman, D., Lallinger, K., Abraham, W. T., … Sanders, G. D. (2020). Future research prioritization in cardiac resynchronization therapy. Am Heart J, 223, 48–58. https://doi.org/10.1016/j.ahj.2020.02.011
Fudim, Marat, Frederik Dalgaard, Sana M. Al-Khatib, Daniel J Friedman, Kathryn Lallinger, William T. Abraham, John G. F. Cleland, et al. “Future research prioritization in cardiac resynchronization therapy.Am Heart J 223 (May 2020): 48–58. https://doi.org/10.1016/j.ahj.2020.02.011.
Fudim M, Dalgaard F, Al-Khatib SM, J Friedman D, Lallinger K, Abraham WT, et al. Future research prioritization in cardiac resynchronization therapy. Am Heart J. 2020 May;223:48–58.
Fudim, Marat, et al. “Future research prioritization in cardiac resynchronization therapy.Am Heart J, vol. 223, May 2020, pp. 48–58. Pubmed, doi:10.1016/j.ahj.2020.02.011.
Fudim M, Dalgaard F, Al-Khatib SM, J Friedman D, Lallinger K, Abraham WT, Cleland JGF, Curtis AB, Gold MR, Kutyifa V, Linde C, Schaber DE, Tang A, Ali-Ahmed F, Goldstein SA, Kaufman B, Fortman R, Davis JK, Inoue LYT, Sanders GD. Future research prioritization in cardiac resynchronization therapy. Am Heart J. 2020 May;223:48–58.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2020

Volume

223

Start / End Page

48 / 58

Location

United States

Related Subject Headings

  • Stroke Volume
  • Research
  • Humans
  • Heart Failure
  • Forecasting
  • Cardiovascular System & Hematology
  • Cardiac Resynchronization Therapy
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology