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The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata.

Publication ,  Journal Article
Meah, N; Wall, D; York, K; Bhoyrul, B; Bokhari, L; Sigall, DA; Bergfeld, WF; Betz, RC; Blume-Peytavi, U; Callender, V; Chitreddy, V; Eisman, S ...
Published in: J Am Acad Dermatol
July 2020

BACKGROUND: A systematic review failed to identify any systemic therapy used in alopecia areata (AA) where use is supported by robust evidence from high-quality randomized controlled trials. OBJECTIVE: To produce an international consensus statement on the use and utility of various treatments for AA. METHODS: Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Agreement of 66% or greater was considered consensus. RESULTS: In the first round, consensus was achieved in 22 of 423 (5%) questions. After a face-to-face meeting in round 3, overall, consensus was achieved for only 130 (33%) treatment-specific questions. There was greater consensus for intralesional treatment of AA (19 [68%]) followed by topical treatment (25 [43%]). Consensus was achieved in 45 (36%) questions pertaining to systemic therapies in AA. The categories with the least consensus were phototherapy and nonprescription therapies. LIMITATIONS: The study included a comprehensive list of systemic treatments for AA but not all treatments used. CONCLUSION: Despite divergent opinions among experts, consensus was achieved on a number of pertinent questions. The concluding statement also highlights areas where expert consensus is lacking and where an international patient registry could enable further research.

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Published In

J Am Acad Dermatol

DOI

EISSN

1097-6787

Publication Date

July 2020

Volume

83

Issue

1

Start / End Page

123 / 130

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Severity of Illness Index
  • Phototherapy
  • Injections, Intralesional
  • Humans
  • Expert Testimony
  • Dermatology & Venereal Diseases
  • Dermatologic Agents
  • Delphi Technique
  • Complementary Therapies
 

Citation

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Meah, N., Wall, D., York, K., Bhoyrul, B., Bokhari, L., Sigall, D. A., … Sinclair, R. (2020). The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata. J Am Acad Dermatol, 83(1), 123–130. https://doi.org/10.1016/j.jaad.2020.03.004
Meah, Nekma, Dmitri Wall, Katherine York, Bevin Bhoyrul, Laita Bokhari, Daniel Asz Sigall, Wilma F. Bergfeld, et al. “The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata.J Am Acad Dermatol 83, no. 1 (July 2020): 123–30. https://doi.org/10.1016/j.jaad.2020.03.004.
Meah N, Wall D, York K, Bhoyrul B, Bokhari L, Sigall DA, et al. The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata. J Am Acad Dermatol. 2020 Jul;83(1):123–30.
Meah, Nekma, et al. “The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata.J Am Acad Dermatol, vol. 83, no. 1, July 2020, pp. 123–30. Pubmed, doi:10.1016/j.jaad.2020.03.004.
Meah N, Wall D, York K, Bhoyrul B, Bokhari L, Sigall DA, Bergfeld WF, Betz RC, Blume-Peytavi U, Callender V, Chitreddy V, Combalia A, Cotsarelis G, Craiglow B, Donovan J, Eisman S, Farrant P, Green J, Grimalt R, Harries M, Hordinsky M, Irvine AD, Itami S, Jolliffe V, King B, Lee W-S, McMichael A, Messenger A, Mirmirani P, Olsen E, Orlow SJ, Piraccini BM, Rakowska A, Reygagne P, Roberts JL, Rudnicka L, Shapiro J, Sharma P, Tosti A, Vogt A, Wade M, Yip L, Zlotogorski A, Sinclair R. The Alopecia Areata Consensus of Experts (ACE) study: Results of an international expert opinion on treatments for alopecia areata. J Am Acad Dermatol. 2020 Jul;83(1):123–130.
Journal cover image

Published In

J Am Acad Dermatol

DOI

EISSN

1097-6787

Publication Date

July 2020

Volume

83

Issue

1

Start / End Page

123 / 130

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Severity of Illness Index
  • Phototherapy
  • Injections, Intralesional
  • Humans
  • Expert Testimony
  • Dermatology & Venereal Diseases
  • Dermatologic Agents
  • Delphi Technique
  • Complementary Therapies