Skip to main content
Journal cover image

Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology.

Publication ,  Journal Article
Pasipoularides, A
Published in: Int J Cardiol
March 1, 2017

For most of Medicine's past, the best that physicians could do to cope with disease prevention and treatment was based on the expected response of an average patient. Currently, however, a more personalized/precise approach to cardiology and medicine in general is becoming possible, as the cost of sequencing a human genome has declined substantially. As a result, we are witnessing an era of precipitous advances in biomedicine and bourgeoning understanding of the genetic basis of cardiovascular and other diseases, reminiscent of the resurgence of innovations in physico-mathematical sciences and biology-anatomy-cardiology in the Renaissance, a parallel time of radical change and reformation of medical knowledge, education and practice. Now on the horizon is an individualized, diverse patient-centered, approach to medical practice that encompasses the development of new, gene-based diagnostics and preventive medicine tactics, and offers the broadest range of personalized therapies based on pharmacogenetics. Over time, translation of genomic and high-tech approaches unquestionably will transform clinical practice in cardiology and medicine as a whole, with the adoption of new personalized medicine approaches and procedures. Clearly, future prospects far outweigh present accomplishments, which are best viewed as a promising start. It is now essential for pluridisciplinary health care providers to examine the drivers and barriers to the clinical adoption of this emerging revolutionary paradigm, in order to expedite the realization of its potential. So, we are not there yet, but we are definitely on our way.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Int J Cardiol

DOI

EISSN

1874-1754

Publication Date

March 1, 2017

Volume

230

Start / End Page

384 / 401

Location

Netherlands

Related Subject Headings

  • Translational Research, Biomedical
  • Precision Medicine
  • Humans
  • Genomics
  • Cardiovascular System & Hematology
  • Cardiology
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pasipoularides, A. (2017). Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology. Int J Cardiol, 230, 384–401. https://doi.org/10.1016/j.ijcard.2016.12.097
Pasipoularides, Ares. “Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology.Int J Cardiol 230 (March 1, 2017): 384–401. https://doi.org/10.1016/j.ijcard.2016.12.097.
Pasipoularides, Ares. “Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology.Int J Cardiol, vol. 230, Mar. 2017, pp. 384–401. Pubmed, doi:10.1016/j.ijcard.2016.12.097.
Journal cover image

Published In

Int J Cardiol

DOI

EISSN

1874-1754

Publication Date

March 1, 2017

Volume

230

Start / End Page

384 / 401

Location

Netherlands

Related Subject Headings

  • Translational Research, Biomedical
  • Precision Medicine
  • Humans
  • Genomics
  • Cardiovascular System & Hematology
  • Cardiology
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology