Anti-HIV tigliane diterpenoids from Reutealis trisperma.
Publication
, Journal Article
Lu, Y; Huang, Y-S; Chen, C-H; Akiyama, T; Morris-Natschke, SL; Cheng, Y-Y; Chen, I-S; Yang, S-Z; Chen, D-F; Lee, K-H
Published in: Phytochemistry
June 2020
Bioassay-guided fractionation of the n-butanol extract from the branches and leaves of Reutealis trisperma resulted in the isolation of six undescribed (crotignoids L ~ Q) together with two known (12-deoxyphorbol-13-hexadecanoate and 12-deoxyphorbol-13-myristate) tigliane diterpenoids. Their structures, especially the absolute configurations, were determined from extensive spectroscopic studies, including 2D NMR spectra, CD data analysis and electronic circular dichroism (ECD) calculations. All isolates were tested for anti-HIV activity against HL4-3 virus in MT4 cells. Except for crotignoid Q, the remaining seven tigliane diterpenoids exhibited potent anti-HIV activity with IC50 values ranging from 0.0023 to 4.03 μM.
Duke Scholars
Published In
Phytochemistry
DOI
EISSN
1873-3700
Publication Date
June 2020
Volume
174
Start / End Page
112360
Location
England
Related Subject Headings
- Plant Biology & Botany
- Phorbols
- Molecular Structure
- Euphorbiaceae
- Drugs, Chinese Herbal
- Diterpenes
- 3108 Plant biology
- 11 Medical and Health Sciences
- 06 Biological Sciences
- 03 Chemical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Lu, Y., Huang, Y.-S., Chen, C.-H., Akiyama, T., Morris-Natschke, S. L., Cheng, Y.-Y., … Lee, K.-H. (2020). Anti-HIV tigliane diterpenoids from Reutealis trisperma. Phytochemistry, 174, 112360. https://doi.org/10.1016/j.phytochem.2020.112360
Lu, Yan, Ya-Si Huang, Chin-Ho Chen, Toshiyuki Akiyama, Susan L. Morris-Natschke, Yung-Yi Cheng, Ih-Sheng Chen, Sheng-Zehn Yang, Dao-Feng Chen, and Kuo-Hsiung Lee. “Anti-HIV tigliane diterpenoids from Reutealis trisperma.” Phytochemistry 174 (June 2020): 112360. https://doi.org/10.1016/j.phytochem.2020.112360.
Lu Y, Huang Y-S, Chen C-H, Akiyama T, Morris-Natschke SL, Cheng Y-Y, et al. Anti-HIV tigliane diterpenoids from Reutealis trisperma. Phytochemistry. 2020 Jun;174:112360.
Lu, Yan, et al. “Anti-HIV tigliane diterpenoids from Reutealis trisperma.” Phytochemistry, vol. 174, June 2020, p. 112360. Pubmed, doi:10.1016/j.phytochem.2020.112360.
Lu Y, Huang Y-S, Chen C-H, Akiyama T, Morris-Natschke SL, Cheng Y-Y, Chen I-S, Yang S-Z, Chen D-F, Lee K-H. Anti-HIV tigliane diterpenoids from Reutealis trisperma. Phytochemistry. 2020 Jun;174:112360.
Published In
Phytochemistry
DOI
EISSN
1873-3700
Publication Date
June 2020
Volume
174
Start / End Page
112360
Location
England
Related Subject Headings
- Plant Biology & Botany
- Phorbols
- Molecular Structure
- Euphorbiaceae
- Drugs, Chinese Herbal
- Diterpenes
- 3108 Plant biology
- 11 Medical and Health Sciences
- 06 Biological Sciences
- 03 Chemical Sciences