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Plasma fibrinogen levels and their correlates in 6457 coronary heart disease patients. The Bezafibrate Infarction Prevention (BIP) Study.

Publication ,  Journal Article
Barasch, E; Benderly, M; Graff, E; Behar, S; Reicher-Reiss, H; Caspi, A; Pelled, B; Reisin, L; Roguin, N; Goldbourt, U
Published in: Journal of clinical epidemiology
June 1995

The association between fibrinogen measured in healthy individuals and subsequent development of ischemic heart disease is well established, but studies reporting fibrinogen levels in coronary heart disease patients are scarce. Plasma fibrinogen was determined for 5729 men and 728 women (aged 45 to 74) with established coronary heart disease, screened for participation in the Bezafibrate Infarction Prevention study, with the following lipid profile at the time of the first screening visit: total serum cholesterol < or = 270 mg/dl, high density lipoprotein cholesterol < or = 45 mg/dl and triglyceride < or = 300 mg/dl. Increased age was associated with augmented plasma fibrinogen values. Age-adjusted fibrinogen levels were higher in women than in men. A direct association was found between mean fibrinogen levels and low density lipoprotein cholesterol. On the other hand, the correlation with high density lipoprotein cholesterol was inverse. Fibrinogen was also associated with body mass index, behavioral variables and severity of coronary heart disease. In a multivariable linear regression analysis performed, risk factors considered explained merely 6 and 4% of fibrinogen variation for men and women, respectively. Therefore, most of the fibrinogen level variability in coronary heart disease patients is accounted for by factors that remain to be established by further research.

Duke Scholars

Published In

Journal of clinical epidemiology

DOI

EISSN

1878-5921

ISSN

0895-4356

Publication Date

June 1995

Volume

48

Issue

6

Start / End Page

757 / 765

Related Subject Headings

  • Triglycerides
  • Smoking
  • Sex Factors
  • Risk Factors
  • Myocardial Infarction
  • Multivariate Analysis
  • Motor Activity
  • Middle Aged
  • Male
  • Israel
 

Citation

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Barasch, E., Benderly, M., Graff, E., Behar, S., Reicher-Reiss, H., Caspi, A., … Goldbourt, U. (1995). Plasma fibrinogen levels and their correlates in 6457 coronary heart disease patients. The Bezafibrate Infarction Prevention (BIP) Study. Journal of Clinical Epidemiology, 48(6), 757–765. https://doi.org/10.1016/0895-4356(94)00191-r
Barasch, E., M. Benderly, E. Graff, S. Behar, H. Reicher-Reiss, A. Caspi, B. Pelled, L. Reisin, N. Roguin, and U. Goldbourt. “Plasma fibrinogen levels and their correlates in 6457 coronary heart disease patients. The Bezafibrate Infarction Prevention (BIP) Study.Journal of Clinical Epidemiology 48, no. 6 (June 1995): 757–65. https://doi.org/10.1016/0895-4356(94)00191-r.
Barasch E, Benderly M, Graff E, Behar S, Reicher-Reiss H, Caspi A, et al. Plasma fibrinogen levels and their correlates in 6457 coronary heart disease patients. The Bezafibrate Infarction Prevention (BIP) Study. Journal of clinical epidemiology. 1995 Jun;48(6):757–65.
Barasch, E., et al. “Plasma fibrinogen levels and their correlates in 6457 coronary heart disease patients. The Bezafibrate Infarction Prevention (BIP) Study.Journal of Clinical Epidemiology, vol. 48, no. 6, June 1995, pp. 757–65. Epmc, doi:10.1016/0895-4356(94)00191-r.
Barasch E, Benderly M, Graff E, Behar S, Reicher-Reiss H, Caspi A, Pelled B, Reisin L, Roguin N, Goldbourt U. Plasma fibrinogen levels and their correlates in 6457 coronary heart disease patients. The Bezafibrate Infarction Prevention (BIP) Study. Journal of clinical epidemiology. 1995 Jun;48(6):757–765.
Journal cover image

Published In

Journal of clinical epidemiology

DOI

EISSN

1878-5921

ISSN

0895-4356

Publication Date

June 1995

Volume

48

Issue

6

Start / End Page

757 / 765

Related Subject Headings

  • Triglycerides
  • Smoking
  • Sex Factors
  • Risk Factors
  • Myocardial Infarction
  • Multivariate Analysis
  • Motor Activity
  • Middle Aged
  • Male
  • Israel