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Recent developments in pediatric retina.

Publication ,  Journal Article
Cai, S; Therattil, A; Vajzovic, L
Published in: Curr Opin Ophthalmol
May 2020

PURPOSE OF REVIEW: Pediatric retina is an exciting, but also challenging field, where patient age and cooperation can limit ease of diagnosis of a broad range of congenital and acquired diseases, inherited retinal degenerations are mostly untreatable and surgical outcomes can be quite different from those for adults. This review aims to highlight some recent advances and trends that are improving our ability to care for children with retinal conditions. RECENT FINDINGS: Studies have demonstrated the feasibility of multimodal imaging even in nonsedated infants, with portable optical coherence tomography (OCT) and OCT angiography in particular offering structural insights into diverse pediatric retinal conditions. Encouraging long-term outcomes of subretinal voretigene neparvovec-rzyl injection for RPE65 mutation-associated Leber congenital amaurosis have inspired research on the optimization of subretinal gene delivery and gene therapy for other inherited retinal degenerations. In retinopathy of prematurity, machine learning and smartphone-based imaging can facilitate screening, and studies have highlighted favorable outcomes from intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections. A nomogram for pediatric pars plana sclerotomy site placement may improve safety in complex surgeries. SUMMARY: Multimodal imaging, gene therapy, machine learning and surgical innovation have been and will continue to be important to advances in pediatric retina.

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Published In

Curr Opin Ophthalmol

DOI

EISSN

1531-7021

Publication Date

May 2020

Volume

31

Issue

3

Start / End Page

155 / 160

Location

United States

Related Subject Headings

  • Retinal Diseases
  • Retina
  • Ophthalmology & Optometry
  • Ophthalmologic Surgical Procedures
  • Multimodal Imaging
  • Machine Learning
  • Infant
  • Humans
  • Genetic Therapy
  • Child, Preschool
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cai, S., Therattil, A., & Vajzovic, L. (2020). Recent developments in pediatric retina. Curr Opin Ophthalmol, 31(3), 155–160. https://doi.org/10.1097/ICU.0000000000000650
Cai, Sophie, Anthony Therattil, and Lejla Vajzovic. “Recent developments in pediatric retina.Curr Opin Ophthalmol 31, no. 3 (May 2020): 155–60. https://doi.org/10.1097/ICU.0000000000000650.
Cai S, Therattil A, Vajzovic L. Recent developments in pediatric retina. Curr Opin Ophthalmol. 2020 May;31(3):155–60.
Cai, Sophie, et al. “Recent developments in pediatric retina.Curr Opin Ophthalmol, vol. 31, no. 3, May 2020, pp. 155–60. Pubmed, doi:10.1097/ICU.0000000000000650.
Cai S, Therattil A, Vajzovic L. Recent developments in pediatric retina. Curr Opin Ophthalmol. 2020 May;31(3):155–160.

Published In

Curr Opin Ophthalmol

DOI

EISSN

1531-7021

Publication Date

May 2020

Volume

31

Issue

3

Start / End Page

155 / 160

Location

United States

Related Subject Headings

  • Retinal Diseases
  • Retina
  • Ophthalmology & Optometry
  • Ophthalmologic Surgical Procedures
  • Multimodal Imaging
  • Machine Learning
  • Infant
  • Humans
  • Genetic Therapy
  • Child, Preschool