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Identification of hepatitis B virus aetiologic antigens, HBx and Pre-S2, in diffuse large B-cell lymphoma.

Publication ,  Journal Article
Huang, X; Young, KH; Guo, W; Wang, Y; Wang, X; Xi, Y; Wang, L; Bai, O
Published in: J Viral Hepat
September 2020

Diffuse large B-cell lymphoma (DLBCL) has been reported to have a significant association with the hepatitis B virus (HBV) infection. However, there has been no experimental evidence to determine whether the components of the hepatitis B virus are expressed in lymphoid cells. In this study, we used immunohistochemical methods to explore whether the antigens of hepatitis B virus are expressed in DLBCL lymphoma cells in HBsAg-positive DLBCL patients (HBsAg + DLBCL). HBx antigen was detected in 48.9% of HBsAg + DLBCL patients, and the expression rate of the Pre-S2 antigen was 57.2%. HBx expression was significantly associated with high-level expression of c-Myc, while the Pre-S2 antigen was not. In this study, we demonstrated that HBx antigen and Pre-S2 antigen could be detected in lymphoma cells, and HBx expression was related to c-Myc expression. Our findings provide a strong basis for further study of the HBV-infected DLBCL and molecular mechanism underlying the lymphomagenesis.

Duke Scholars

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Published In

J Viral Hepat

DOI

EISSN

1365-2893

Publication Date

September 2020

Volume

27

Issue

9

Start / End Page

948 / 950

Location

England

Related Subject Headings

  • Viral Regulatory and Accessory Proteins
  • Trans-Activators
  • Lymphoma, Large B-Cell, Diffuse
  • Humans
  • Hepatitis B virus
  • Hepatitis B Surface Antigens
  • Hepatitis B
  • Gastroenterology & Hepatology
  • 3207 Medical microbiology
  • 3202 Clinical sciences
 

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Huang, X., Young, K. H., Guo, W., Wang, Y., Wang, X., Xi, Y., … Bai, O. (2020). Identification of hepatitis B virus aetiologic antigens, HBx and Pre-S2, in diffuse large B-cell lymphoma. J Viral Hepat, 27(9), 948–950. https://doi.org/10.1111/jvh.13301
Huang, Xinxing, Ken H. Young, Wei Guo, Yinping Wang, Xueju Wang, Yanfeng Xi, Lifen Wang, and Ou Bai. “Identification of hepatitis B virus aetiologic antigens, HBx and Pre-S2, in diffuse large B-cell lymphoma.J Viral Hepat 27, no. 9 (September 2020): 948–50. https://doi.org/10.1111/jvh.13301.
Huang X, Young KH, Guo W, Wang Y, Wang X, Xi Y, et al. Identification of hepatitis B virus aetiologic antigens, HBx and Pre-S2, in diffuse large B-cell lymphoma. J Viral Hepat. 2020 Sep;27(9):948–50.
Huang, Xinxing, et al. “Identification of hepatitis B virus aetiologic antigens, HBx and Pre-S2, in diffuse large B-cell lymphoma.J Viral Hepat, vol. 27, no. 9, Sept. 2020, pp. 948–50. Pubmed, doi:10.1111/jvh.13301.
Huang X, Young KH, Guo W, Wang Y, Wang X, Xi Y, Wang L, Bai O. Identification of hepatitis B virus aetiologic antigens, HBx and Pre-S2, in diffuse large B-cell lymphoma. J Viral Hepat. 2020 Sep;27(9):948–950.
Journal cover image

Published In

J Viral Hepat

DOI

EISSN

1365-2893

Publication Date

September 2020

Volume

27

Issue

9

Start / End Page

948 / 950

Location

England

Related Subject Headings

  • Viral Regulatory and Accessory Proteins
  • Trans-Activators
  • Lymphoma, Large B-Cell, Diffuse
  • Humans
  • Hepatitis B virus
  • Hepatitis B Surface Antigens
  • Hepatitis B
  • Gastroenterology & Hepatology
  • 3207 Medical microbiology
  • 3202 Clinical sciences