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Grafting To of Bottlebrush Polymers: Conformation and Kinetics.

Publication ,  Journal Article
Navarro, LA; Shah, TP; Zauscher, S
Published in: Langmuir : the ACS journal of surfaces and colloids
May 2020

Specifically adsorbed bottlebrush coatings are found in nature as brush-like glycoproteins that decorate biointerfaces and provide antifouling, lubrication, or wear-protection. Although various synthetic strategies have been developed to mimic glycoprotein structure and function, the use of these mimics is still limited because of the current lack of understanding of their adsorption behavior and surface conformation. In this paper, we examine the adsorption behavior of PEG-based, biotinylated bottlebrushes with different backbone and bristle lengths to streptavidin model surfaces in phosphate-buffered saline. By using quartz crystal microbalance, localized surface plasmon resonance, and atomic force microscopy, we learn how bottlebrush dimensions impact their adsorption kinetics, surface conformation, mechanical properties, and antifouling properties. Our bottlebrushes qualitatively mirror the adsorption behavior of linear polymers and exhibit three kinetic regimes of adsorption: (I) a transport-limited regime, (II) a pause, and (III) a penetration-limited regime. Furthermore, we find that the bristle length more dramatically affects brush properties than the backbone length. Generally, larger bottlebrush dimensions lead to reduced molar adsorption, retarded kinetics, weaker antifouling, and softer brush coatings. Longer bristles also lead to less mass adsorption, while the opposite trend is observed for increasing backbone length. In summary, our findings aid the rational design of new bottlebrush coatings by elucidating how their dimensions impact adsorption, surface conformation, and the properties of the final coating.

Duke Scholars

Published In

Langmuir : the ACS journal of surfaces and colloids

DOI

EISSN

1520-5827

ISSN

0743-7463

Publication Date

May 2020

Volume

36

Issue

17

Start / End Page

4745 / 4756

Related Subject Headings

  • Chemical Physics
 

Citation

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ICMJE
MLA
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Navarro, L. A., Shah, T. P., & Zauscher, S. (2020). Grafting To of Bottlebrush Polymers: Conformation and Kinetics. Langmuir : The ACS Journal of Surfaces and Colloids, 36(17), 4745–4756. https://doi.org/10.1021/acs.langmuir.9b03620
Navarro, Luis A., Tejank P. Shah, and Stefan Zauscher. “Grafting To of Bottlebrush Polymers: Conformation and Kinetics.Langmuir : The ACS Journal of Surfaces and Colloids 36, no. 17 (May 2020): 4745–56. https://doi.org/10.1021/acs.langmuir.9b03620.
Navarro LA, Shah TP, Zauscher S. Grafting To of Bottlebrush Polymers: Conformation and Kinetics. Langmuir : the ACS journal of surfaces and colloids. 2020 May;36(17):4745–56.
Navarro, Luis A., et al. “Grafting To of Bottlebrush Polymers: Conformation and Kinetics.Langmuir : The ACS Journal of Surfaces and Colloids, vol. 36, no. 17, May 2020, pp. 4745–56. Epmc, doi:10.1021/acs.langmuir.9b03620.
Navarro LA, Shah TP, Zauscher S. Grafting To of Bottlebrush Polymers: Conformation and Kinetics. Langmuir : the ACS journal of surfaces and colloids. 2020 May;36(17):4745–4756.
Journal cover image

Published In

Langmuir : the ACS journal of surfaces and colloids

DOI

EISSN

1520-5827

ISSN

0743-7463

Publication Date

May 2020

Volume

36

Issue

17

Start / End Page

4745 / 4756

Related Subject Headings

  • Chemical Physics