Lipoprotein (a): An Update on a Marker of Residual Risk and Associated Clinical Manifestations.
Lipoprotein (a) [Lp(a)] is a low-density, cholesterol-containing lipoprotein that differs from other low-density lipoproteins due to the presence of apolipoprotein(a) bound to its surface apolipoprotein B100. Multiple epidemiologic studies, including Mendelian Randomization studies, have demonstrated that increasing Lp(a) levels are associated with increased risk of heart disease, including atherosclerotic cardiovascular disease and calcific aortic stenosis. The risk associated with elevations in Lp(a) appears to be independent of other lipid markers. While the current treatment options for elevated Lp(a) are limited, promising new therapies are under development, leading to renewed interest in Lp(a). This review provides an overview of the biology and epidemiology of Lp(a), available outcome studies, and insights into future therapies.
Duke Scholars
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Related Subject Headings
- Stroke
- Secondary Prevention
- Risk Assessment
- Primary Prevention
- Peripheral Arterial Disease
- Oligonucleotides, Antisense
- Lipoprotein(a)
- Humans
- Genetic Predisposition to Disease
- Diabetes Mellitus
Citation
Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Stroke
- Secondary Prevention
- Risk Assessment
- Primary Prevention
- Peripheral Arterial Disease
- Oligonucleotides, Antisense
- Lipoprotein(a)
- Humans
- Genetic Predisposition to Disease
- Diabetes Mellitus