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Expression and mutation analysis of the Wilms' tumor 1 gene in human neural tumors.

Publication ,  Journal Article
Dennis, SL; Manji, SSM; Carrington, DP; Scarcella, DL; Ashley, DM; Smith, PJ; Algar, EM
Published in: Int J Cancer
February 10, 2002

The Wilms' tumor 1 gene, WT1, encodes a zinc-finger protein that is implicated in the development of Wilms' tumor. Mutant or aberrantly expressed WT1 isoforms have also been described in desmoplastic small round cell tumor, acute leukemias, mesothelioma, breast tumors and melanoma. During early development, WT1 is expressed in the brain and spinal cord, however its role in the malignancies that affect these tissues has not been previously investigated. In our study we have examined neural tumors including brain tumors and neuroblastomas for WT1 expression and for mutations affecting the zinc-fingers. Although WT1 expression was detected in gliomas, medulloblastomas and neuroblastomas, neither zinc-finger region mutations nor splicing anomalies affecting the KTS site were detected. We therefore conclude that WT1 does not play a significant role in the etiology of human neural tumors.

Duke Scholars

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

February 10, 2002

Volume

97

Issue

5

Start / End Page

713 / 715

Location

United States

Related Subject Headings

  • Zinc Fingers
  • WT1 Proteins
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Oncology & Carcinogenesis
  • Neuroblastoma
  • Medulloblastoma
  • Humans
  • Glioma
  • DNA Mutational Analysis
 

Citation

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Dennis, S. L., Manji, S. S. M., Carrington, D. P., Scarcella, D. L., Ashley, D. M., Smith, P. J., & Algar, E. M. (2002). Expression and mutation analysis of the Wilms' tumor 1 gene in human neural tumors. Int J Cancer, 97(5), 713–715. https://doi.org/10.1002/ijc.10106
Dennis, Sally L., Shehnaaz S. M. Manji, Darryl P. Carrington, Deborah L. Scarcella, David M. Ashley, Peter J. Smith, and Elizabeth M. Algar. “Expression and mutation analysis of the Wilms' tumor 1 gene in human neural tumors.Int J Cancer 97, no. 5 (February 10, 2002): 713–15. https://doi.org/10.1002/ijc.10106.
Dennis SL, Manji SSM, Carrington DP, Scarcella DL, Ashley DM, Smith PJ, et al. Expression and mutation analysis of the Wilms' tumor 1 gene in human neural tumors. Int J Cancer. 2002 Feb 10;97(5):713–5.
Dennis, Sally L., et al. “Expression and mutation analysis of the Wilms' tumor 1 gene in human neural tumors.Int J Cancer, vol. 97, no. 5, Feb. 2002, pp. 713–15. Pubmed, doi:10.1002/ijc.10106.
Dennis SL, Manji SSM, Carrington DP, Scarcella DL, Ashley DM, Smith PJ, Algar EM. Expression and mutation analysis of the Wilms' tumor 1 gene in human neural tumors. Int J Cancer. 2002 Feb 10;97(5):713–715.
Journal cover image

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

February 10, 2002

Volume

97

Issue

5

Start / End Page

713 / 715

Location

United States

Related Subject Headings

  • Zinc Fingers
  • WT1 Proteins
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA, Messenger
  • Oncology & Carcinogenesis
  • Neuroblastoma
  • Medulloblastoma
  • Humans
  • Glioma
  • DNA Mutational Analysis