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Treatment of high risk or recurrent meningiomas with hydroxyurea.

Publication ,  Journal Article
Rosenthal, MA; Ashley, DL; Cher, L
Published in: J Clin Neurosci
March 2002

Recurrent, irresectable meningioma constitutes an uncommon but significant problem. Many systemic therapies have been tested without clear evidence of efficacy. More recently, two reports have suggested that hydroxyurea has activity in this context. This study examined the efficacy and toxicity of hydroxyurea in the treatment of 15 patients with high risk meningioma, residual meningioma post resection and progressive meningioma. Hydroxyurea was well tolerated although two patients ceased therapy because of skin rashes. There were no objective responses. Eleven patients achieved stable disease including eight patients who had documented progression prior to commencing hydroxyurea. These results are consistent with previous reports. In conclusion, hydroxyurea may provide some clinical benefit in patients with progressive meningioma by delaying progression of disease.

Duke Scholars

Published In

J Clin Neurosci

DOI

ISSN

0967-5868

Publication Date

March 2002

Volume

9

Issue

2

Start / End Page

156 / 158

Location

Scotland

Related Subject Headings

  • Risk Factors
  • Neurology & Neurosurgery
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Meningioma
  • Meningeal Neoplasms
  • Male
  • Hydroxyurea
  • Humans
  • Female
 

Citation

APA
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Rosenthal, M. A., Ashley, D. L., & Cher, L. (2002). Treatment of high risk or recurrent meningiomas with hydroxyurea. J Clin Neurosci, 9(2), 156–158. https://doi.org/10.1054/jocn.2001.1019
Rosenthal, Mark A., David L. Ashley, and Lawrence Cher. “Treatment of high risk or recurrent meningiomas with hydroxyurea.J Clin Neurosci 9, no. 2 (March 2002): 156–58. https://doi.org/10.1054/jocn.2001.1019.
Rosenthal MA, Ashley DL, Cher L. Treatment of high risk or recurrent meningiomas with hydroxyurea. J Clin Neurosci. 2002 Mar;9(2):156–8.
Rosenthal, Mark A., et al. “Treatment of high risk or recurrent meningiomas with hydroxyurea.J Clin Neurosci, vol. 9, no. 2, Mar. 2002, pp. 156–58. Pubmed, doi:10.1054/jocn.2001.1019.
Rosenthal MA, Ashley DL, Cher L. Treatment of high risk or recurrent meningiomas with hydroxyurea. J Clin Neurosci. 2002 Mar;9(2):156–158.
Journal cover image

Published In

J Clin Neurosci

DOI

ISSN

0967-5868

Publication Date

March 2002

Volume

9

Issue

2

Start / End Page

156 / 158

Location

Scotland

Related Subject Headings

  • Risk Factors
  • Neurology & Neurosurgery
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Meningioma
  • Meningeal Neoplasms
  • Male
  • Hydroxyurea
  • Humans
  • Female