DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia.
Publication
, Journal Article
Chatterton, Z; Morenos, L; Saffery, R; Craig, JM; Ashley, D; Wong, NC
Published in: Epigenomics
October 2010
Acute lymphoblastic leukemia (ALL) is the most common cancer in children in the modern world. Recent efforts in characterizing the genetic contribution to this disease through uncovering gene mutations, deletions and structural variation by genome-scale methods have only accounted for a modest proportion of children with ALL. This suggests that either further genetic contributions to ALL have yet to be characterized or other factors, such as epigenetic aberrations are involved. A number of DNA methylation and miRNA profiling studies have investigated the role of both in childhood ALL. Here, we review these profiling efforts, summarize their major findings and speculate as to what the future may hold.
Duke Scholars
Published In
Epigenomics
DOI
EISSN
1750-192X
Publication Date
October 2010
Volume
2
Issue
5
Start / End Page
697 / 708
Location
England
Related Subject Headings
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- MicroRNAs
- Humans
- High-Throughput Screening Assays
- Epigenesis, Genetic
- DNA Methylation
- Child
- Biomarkers, Tumor
- 3105 Genetics
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Chatterton, Z., Morenos, L., Saffery, R., Craig, J. M., Ashley, D., & Wong, N. C. (2010). DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia. Epigenomics, 2(5), 697–708. https://doi.org/10.2217/epi.10.39
Chatterton, Zac, Leah Morenos, Richard Saffery, Jeffrey M. Craig, David Ashley, and Nicholas C. Wong. “DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia.” Epigenomics 2, no. 5 (October 2010): 697–708. https://doi.org/10.2217/epi.10.39.
Chatterton Z, Morenos L, Saffery R, Craig JM, Ashley D, Wong NC. DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia. Epigenomics. 2010 Oct;2(5):697–708.
Chatterton, Zac, et al. “DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia.” Epigenomics, vol. 2, no. 5, Oct. 2010, pp. 697–708. Pubmed, doi:10.2217/epi.10.39.
Chatterton Z, Morenos L, Saffery R, Craig JM, Ashley D, Wong NC. DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia. Epigenomics. 2010 Oct;2(5):697–708.
Published In
Epigenomics
DOI
EISSN
1750-192X
Publication Date
October 2010
Volume
2
Issue
5
Start / End Page
697 / 708
Location
England
Related Subject Headings
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- MicroRNAs
- Humans
- High-Throughput Screening Assays
- Epigenesis, Genetic
- DNA Methylation
- Child
- Biomarkers, Tumor
- 3105 Genetics
- 1103 Clinical Sciences