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Co-occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines. Part II.

Publication ,  Journal Article
Capone, G; Stephens, M; Santoro, S; Chicoine, B; Bulova, P; Peterson, M; Jasien, J; Smith, AJ ...
Published in: Am J Med Genet A
July 2020

Adults with Down syndrome (DS) represent a unique population who are in need of clinical guidelines to address their medical care. Many of these conditions are of public health importance with the potential to develop screening recommendations to improve clinical care for this population. Our workgroup previously identified and prioritized co-occurring medical conditions in adults with DS. In this study, we again performed detailed literature searches on an additional six medical conditions of clinical importance. A series of key questions (KQ) were formulated a priori to guide the literature search strategy. Our KQs focused on disease prevalence, severity, risk-factors, methodologies for screening/evaluation, impact on morbidity, and potential costs/benefits. The available evidence was extracted, evaluated and graded on quality. The number of participants and the design of clinical studies varied by condition and were often inadequate for answering most of the KQ. Based upon our review, we provide a summary of the findings on hip dysplasia, menopause, acquired cardiac valve disease, type 2 diabetes mellitus, hematologic disorders, and dysphagia. Minimal evidence demonstrates significant gaps in our clinical knowledge that compromises clinical decision-making and management of these medically complex individuals. The creation of evidence-based clinical guidance for this population will not be possible until these gaps are addressed.

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Published In

Am J Med Genet A

DOI

EISSN

1552-4833

Publication Date

July 2020

Volume

182

Issue

7

Start / End Page

1832 / 1845

Location

United States

Related Subject Headings

  • Risk Factors
  • Mass Screening
  • Male
  • Humans
  • Hematologic Diseases
  • Guidelines as Topic
  • Female
  • Down Syndrome
  • Diabetes Mellitus, Type 2
  • Delivery of Health Care
 

Citation

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Capone, G., Stephens, M., Santoro, S., Chicoine, B., Bulova, P., Peterson, M., … Down Syndrome Medical Interest Group (DSMIG-USA) Adult Health Workgroup, . (2020). Co-occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines. Part II. Am J Med Genet A, 182(7), 1832–1845. https://doi.org/10.1002/ajmg.a.61604
Capone, George, Mary Stephens, Stephanie Santoro, Brian Chicoine, Peter Bulova, Moya Peterson, Joan Jasien, Anna Jo Smith, and Anna Jo Down Syndrome Medical Interest Group (DSMIG-USA) Adult Health Workgroup. “Co-occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines. Part II.Am J Med Genet A 182, no. 7 (July 2020): 1832–45. https://doi.org/10.1002/ajmg.a.61604.
Capone G, Stephens M, Santoro S, Chicoine B, Bulova P, Peterson M, et al. Co-occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines. Part II. Am J Med Genet A. 2020 Jul;182(7):1832–45.
Capone, George, et al. “Co-occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines. Part II.Am J Med Genet A, vol. 182, no. 7, July 2020, pp. 1832–45. Pubmed, doi:10.1002/ajmg.a.61604.
Capone G, Stephens M, Santoro S, Chicoine B, Bulova P, Peterson M, Jasien J, Smith AJ, Down Syndrome Medical Interest Group (DSMIG-USA) Adult Health Workgroup. Co-occurring medical conditions in adults with Down syndrome: A systematic review toward the development of health care guidelines. Part II. Am J Med Genet A. 2020 Jul;182(7):1832–1845.
Journal cover image

Published In

Am J Med Genet A

DOI

EISSN

1552-4833

Publication Date

July 2020

Volume

182

Issue

7

Start / End Page

1832 / 1845

Location

United States

Related Subject Headings

  • Risk Factors
  • Mass Screening
  • Male
  • Humans
  • Hematologic Diseases
  • Guidelines as Topic
  • Female
  • Down Syndrome
  • Diabetes Mellitus, Type 2
  • Delivery of Health Care