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Biomarkers Associated with Physical Resilience After Hip Fracture.

Publication ,  Journal Article
Parker, DC; Colόn-Emeric, C; Huebner, JL; Chou, C-H; Kraus, VB; Pieper, CF; Sloane, R; Whitson, HE; Orwig, D; Crabtree, DM; Magaziner, J ...
Published in: J Gerontol A Biol Sci Med Sci
September 25, 2020

BACKGROUND: Clinically similar older adults demonstrate variable responses to health stressors, heterogeneity attributable to differences in physical resilience. However, molecular mechanisms underlying physical resilience are unknown. We previously derived a measure of physical resilience after hip fracture-the expected recovery differential (ERD)-that captures the difference between actual recovery and predicted recovery. Starting with biomarkers associated with physical performance, morbidity, mortality, and hip fracture, we evaluated associations with the ERD to identify biomarkers of physical resilience after hip fracture. METHODS: In the Baltimore Hip Studies (N = 304) sera, we quantified biomarkers of inflammation (TNFR-I, TNFR-II, sVCAM-1, and IL-6), metabolic and mitochondrial function (non-esterified fatty acids, lactate, ketones, acylcarnitines, free amino acids, and IGF-1), and epigenetic dysregulation (circulating microRNAs). We used principal component analysis, canonical correlation, and least absolute shrinkage and selection operator regression (LASSO) to identify biomarker associations with better-than-expected recovery (greater ERD) after hip fracture. RESULTS: Participants with greater ERD were more likely to be women and less disabled at baseline. The complete biomarker set explained 37% of the variance in ERD (p < .001) by canonical correlation. LASSO regression identified a biomarker subset that accounted for 27% of the total variance in the ERD and included a metabolic factor (aspartate/asparagine, C22, C5:1, lactate, glutamate/mine), TNFR-I, miR-376a-3p, and miR-16-5p. CONCLUSIONS: We identified a set of biomarkers that explained 27% of the variance in ERD-a measure of physical resilience after hip fracture. These ERD-associated biomarkers may be useful in predicting physical resilience in older adults facing hip fracture and other acute health stressors.

Duke Scholars

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Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

September 25, 2020

Volume

75

Issue

10

Start / End Page

e166 / e172

Location

United States

Related Subject Headings

  • Recovery of Function
  • Principal Component Analysis
  • Male
  • Humans
  • Hip Fractures
  • Gerontology
  • Female
  • Biomarkers
  • Baltimore
  • Aged, 80 and over
 

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Parker, D. C., Colόn-Emeric, C., Huebner, J. L., Chou, C.-H., Kraus, V. B., Pieper, C. F., … Huffman, K. M. (2020). Biomarkers Associated with Physical Resilience After Hip Fracture. J Gerontol A Biol Sci Med Sci, 75(10), e166–e172. https://doi.org/10.1093/gerona/glaa119
Parker, Daniel C., Cathleen Colόn-Emeric, Janet L. Huebner, Ching-Heng Chou, Virginia Byers Kraus, Carl F. Pieper, Richard Sloane, et al. “Biomarkers Associated with Physical Resilience After Hip Fracture.J Gerontol A Biol Sci Med Sci 75, no. 10 (September 25, 2020): e166–72. https://doi.org/10.1093/gerona/glaa119.
Parker DC, Colόn-Emeric C, Huebner JL, Chou C-H, Kraus VB, Pieper CF, et al. Biomarkers Associated with Physical Resilience After Hip Fracture. J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):e166–72.
Parker, Daniel C., et al. “Biomarkers Associated with Physical Resilience After Hip Fracture.J Gerontol A Biol Sci Med Sci, vol. 75, no. 10, Sept. 2020, pp. e166–72. Pubmed, doi:10.1093/gerona/glaa119.
Parker DC, Colόn-Emeric C, Huebner JL, Chou C-H, Kraus VB, Pieper CF, Sloane R, Whitson HE, Orwig D, Crabtree DM, Magaziner J, Bain JR, Muehlbauer M, Ilkayeva OR, Huffman KM. Biomarkers Associated with Physical Resilience After Hip Fracture. J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):e166–e172.
Journal cover image

Published In

J Gerontol A Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

September 25, 2020

Volume

75

Issue

10

Start / End Page

e166 / e172

Location

United States

Related Subject Headings

  • Recovery of Function
  • Principal Component Analysis
  • Male
  • Humans
  • Hip Fractures
  • Gerontology
  • Female
  • Biomarkers
  • Baltimore
  • Aged, 80 and over