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Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls.

Publication ,  Journal Article
Zhao, Q; Sullivan, EV; Műller-Oehring, EM; Honnorat, N; Adeli, E; Podhajsky, S; Baker, FC; Colrain, IM; Prouty, D; Tapert, SF; Brown, SA ...
Published in: Addict Biol
March 2021

Exogenous causes, such as alcohol use, and endogenous factors, such as temperament and sex, can modulate developmental trajectories of adolescent neurofunctional maturation. We examined how these factors affect sexual dimorphism in brain functional networks in youth drinking below diagnostic threshold for alcohol use disorder (AUD). Based on the 3-year, annually acquired, longitudinal resting-state functional magnetic resonance imaging (MRI) data of 526 adolescents (12-21 years at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) cohort, developmental trajectories of 23 intrinsic functional networks (IFNs) were analyzed for (1) sexual dimorphism in 259 participants who were no-to-low drinkers throughout this period; (2) sex-alcohol interactions in two age- and sex-matched NCANDA subgroups (N = 76 each), half no-to-low, and half moderate-to-heavy drinkers; and (3) moderating effects of gender-specific alcohol dose effects and a multifactorial impulsivity measure on IFN connectivity in all NCANDA participants. Results showed that sex differences in no-to-low drinkers diminished with age in the inferior-occipital network, yet girls had weaker within-network connectivity than boys in six other networks. Effects of adolescent alcohol use were more pronounced in girls than boys in three IFNs. In particular, girls showed greater within-network connectivity in two motor networks with more alcohol consumption, and these effects were mediated by sensation-seeking only in girls. Our results implied that drinking might attenuate the naturally diminishing sexual differences by disrupting the maturation of network efficiency more severely in girls. The sex-alcohol-dose effect might explain why women are at higher risk of alcohol-related health and psychosocial consequences than men.

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Published In

Addict Biol

DOI

EISSN

1369-1600

Publication Date

March 2021

Volume

26

Issue

2

Start / End Page

e12914

Location

United States

Related Subject Headings

  • Young Adult
  • Underage Drinking
  • Substance Abuse
  • Sex Characteristics
  • Patient Acuity
  • Neurodevelopmental Disorders
  • Male
  • Magnetic Resonance Imaging
  • Impulsive Behavior
  • Humans
 

Citation

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Zhao, Q., Sullivan, E. V., Műller-Oehring, E. M., Honnorat, N., Adeli, E., Podhajsky, S., … Pohl, K. M. (2021). Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls. Addict Biol, 26(2), e12914. https://doi.org/10.1111/adb.12914
Zhao, Qingyu, Edith V. Sullivan, Eva M. Műller-Oehring, Nicolas Honnorat, Ehsan Adeli, Simon Podhajsky, Fiona C. Baker, et al. “Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls.Addict Biol 26, no. 2 (March 2021): e12914. https://doi.org/10.1111/adb.12914.
Zhao Q, Sullivan EV, Műller-Oehring EM, Honnorat N, Adeli E, Podhajsky S, et al. Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls. Addict Biol. 2021 Mar;26(2):e12914.
Zhao, Qingyu, et al. “Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls.Addict Biol, vol. 26, no. 2, Mar. 2021, p. e12914. Pubmed, doi:10.1111/adb.12914.
Zhao Q, Sullivan EV, Műller-Oehring EM, Honnorat N, Adeli E, Podhajsky S, Baker FC, Colrain IM, Prouty D, Tapert SF, Brown SA, Meloy MJ, Brumback T, Nagel BJ, Morales AM, Clark DB, Luna B, De Bellis MD, Voyvodic JT, Nooner KB, Pfefferbaum A, Pohl KM. Adolescent alcohol use disrupts functional neurodevelopment in sensation seeking girls. Addict Biol. 2021 Mar;26(2):e12914.
Journal cover image

Published In

Addict Biol

DOI

EISSN

1369-1600

Publication Date

March 2021

Volume

26

Issue

2

Start / End Page

e12914

Location

United States

Related Subject Headings

  • Young Adult
  • Underage Drinking
  • Substance Abuse
  • Sex Characteristics
  • Patient Acuity
  • Neurodevelopmental Disorders
  • Male
  • Magnetic Resonance Imaging
  • Impulsive Behavior
  • Humans