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Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth.

Publication ,  Journal Article
York, TP; Latendresse, SJ; Jackson-Cook, C; Lapato, DM; Moyer, S; Wolen, AR; Roberson-Nay, R; Do, EK; Murphy, SK; Hoyo, C; Fuemmeler, BF; Strauss, JF
Published in: Epigenetics
November 2020

DNA methylation is highly sensitive to in utero perturbations and has an established role in both embryonic development and regulation of gene expression. The foetal genetic component has been previously shown to contribute significantly to the timing of birth, yet little is known about the identity and behaviour of individual genes. The aim of this study was to test the extent genome-wide DNA methylation levels in umbilical cord blood were associated with gestational age at birth (GA). Findings were validated in an independent sample and evidence for the regulation of gene expression was evaluated for cis gene relationships in specimens with multi-omic data. Genome-wide DNA methylation, measured by the Illumina Infinium Human Methylation 450 K BeadChip, was associated with GA for 2,372 CpG probes (5% FDR) in both the Pregnancy, Race, Environment, Genes (PREG) and Newborn Epigenetic Study (NEST) cohorts. Significant probes mapped to 1,640 characterized genes and an association with nearby gene expression measures obtained by the Affymetrix HG-133A microarray was found for 11 genes. Differentially methylated positions were enriched for actively transcribed and enhancer chromatin states, were predominately located outside of CpG islands, and mapped to genes enriched for inflammation and innate immunity ontologies. In both PREG and NEST, the first principal component derived from these probes explained approximately one-half (58.1% and 47.8%, respectively) of the variation in GA. Gene pathways identified are consistent with the hypothesis of pathogen detection and response by the immune system to elicit premature labour as a consequence of unscheduled inflammation.

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Published In

Epigenetics

DOI

EISSN

1559-2308

Publication Date

November 2020

Volume

15

Issue

11

Start / End Page

1243 / 1258

Location

United States

Related Subject Headings

  • Premature Birth
  • Male
  • Infant, Premature
  • Infant, Newborn
  • Immunity, Innate
  • Humans
  • Gestational Age
  • Genome-Wide Association Study
  • Genetic Loci
  • Fetal Blood
 

Citation

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York, T. P., Latendresse, S. J., Jackson-Cook, C., Lapato, D. M., Moyer, S., Wolen, A. R., … Strauss, J. F. (2020). Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth. Epigenetics, 15(11), 1243–1258. https://doi.org/10.1080/15592294.2020.1767277
York, Timothy P., Shawn J. Latendresse, Colleen Jackson-Cook, Dana M. Lapato, Sara Moyer, Aaron R. Wolen, Roxann Roberson-Nay, et al. “Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth.Epigenetics 15, no. 11 (November 2020): 1243–58. https://doi.org/10.1080/15592294.2020.1767277.
York TP, Latendresse SJ, Jackson-Cook C, Lapato DM, Moyer S, Wolen AR, et al. Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth. Epigenetics. 2020 Nov;15(11):1243–58.
York, Timothy P., et al. “Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth.Epigenetics, vol. 15, no. 11, Nov. 2020, pp. 1243–58. Pubmed, doi:10.1080/15592294.2020.1767277.
York TP, Latendresse SJ, Jackson-Cook C, Lapato DM, Moyer S, Wolen AR, Roberson-Nay R, Do EK, Murphy SK, Hoyo C, Fuemmeler BF, Strauss JF. Replicated umbilical cord blood DNA methylation loci associated with gestational age at birth. Epigenetics. 2020 Nov;15(11):1243–1258.

Published In

Epigenetics

DOI

EISSN

1559-2308

Publication Date

November 2020

Volume

15

Issue

11

Start / End Page

1243 / 1258

Location

United States

Related Subject Headings

  • Premature Birth
  • Male
  • Infant, Premature
  • Infant, Newborn
  • Immunity, Innate
  • Humans
  • Gestational Age
  • Genome-Wide Association Study
  • Genetic Loci
  • Fetal Blood