Skip to main content
Journal cover image

National trends in tranexamic acid use in the peripartum period, 2015-2019.

Publication ,  Journal Article
Ahmadzia, HK; Hynds, EB; Amdur, RL; Gimovsky, AC; James, AH; Luban, NLC
Published in: J Thromb Thrombolysis
October 2020

BACKGROUND: The purpose of this study was to measure trends in the use of tranexamic acid (TXA) during delivery in the United States and to evaluate demographic data and morbidity outcomes among these patients. METHODS: This retrospective cohort study includes data from 19 hospitals in the Universal Health Services network. We compared rates of TXA use between January 2015 and June 2019 across geographic sectors. We also evaluated associations of demographic variables and perinatal outcomes of women who received TXA. RESULTS: 209 cases of TXA use were found from analysis of 101,564 deliveries. TXA use increased over time and rates were higher in the West than in Central and East; the slope of increase over years did not differ between regions. Women who received TXA were more likely to have a history of postpartum hemorrhage (59 (28.2%) vs. 2290 (2.2%), P < 0.0001) but were not more likely to have a chronic disease, including diabetes mellitus, hypertension and heart disease. Women who received TXA were more likely to have estimated blood loss greater than or equal to 1000 mL (adjusted odds ratio (aOR) 15.3; 95% CI 11.1-21.1; P < 0.0001). Likelihood of venous thromboembolism was not significantly increased in TXA recipients (aOR 2.0; 95% CI 0.3-14.6; P = 0.49). CONCLUSION: Increasing national trends of TXA use in the peripartum period was observed, with variable increases by geographic region. Likelihood of venous thromboembolism was not significantly increased among women who received TXA. Increasing TXA use throughout the country suggests that updated hemorrhage guidelines from national obstetrical organizations can shape clinical practice.

Duke Scholars

Published In

J Thromb Thrombolysis

DOI

EISSN

1573-742X

Publication Date

October 2020

Volume

50

Issue

3

Start / End Page

746 / 752

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Venous Thromboembolism
  • United States
  • Tranexamic Acid
  • Retrospective Studies
  • Pregnancy Complications, Cardiovascular
  • Pregnancy
  • Postpartum Hemorrhage
  • Peripartum Period
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ahmadzia, H. K., Hynds, E. B., Amdur, R. L., Gimovsky, A. C., James, A. H., & Luban, N. L. C. (2020). National trends in tranexamic acid use in the peripartum period, 2015-2019. J Thromb Thrombolysis, 50(3), 746–752. https://doi.org/10.1007/s11239-020-02141-4
Ahmadzia, Homa K., Elaine B. Hynds, Richard L. Amdur, Alexis C. Gimovsky, Andra H. James, and Naomi L. C. Luban. “National trends in tranexamic acid use in the peripartum period, 2015-2019.J Thromb Thrombolysis 50, no. 3 (October 2020): 746–52. https://doi.org/10.1007/s11239-020-02141-4.
Ahmadzia HK, Hynds EB, Amdur RL, Gimovsky AC, James AH, Luban NLC. National trends in tranexamic acid use in the peripartum period, 2015-2019. J Thromb Thrombolysis. 2020 Oct;50(3):746–52.
Ahmadzia, Homa K., et al. “National trends in tranexamic acid use in the peripartum period, 2015-2019.J Thromb Thrombolysis, vol. 50, no. 3, Oct. 2020, pp. 746–52. Pubmed, doi:10.1007/s11239-020-02141-4.
Ahmadzia HK, Hynds EB, Amdur RL, Gimovsky AC, James AH, Luban NLC. National trends in tranexamic acid use in the peripartum period, 2015-2019. J Thromb Thrombolysis. 2020 Oct;50(3):746–752.
Journal cover image

Published In

J Thromb Thrombolysis

DOI

EISSN

1573-742X

Publication Date

October 2020

Volume

50

Issue

3

Start / End Page

746 / 752

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Venous Thromboembolism
  • United States
  • Tranexamic Acid
  • Retrospective Studies
  • Pregnancy Complications, Cardiovascular
  • Pregnancy
  • Postpartum Hemorrhage
  • Peripartum Period
  • Humans