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Effectiveness of 'catch-up' human papillomavirus vaccination to prevent cervical neoplasia in immunosuppressed and non-immunosuppressed women.

Publication ,  Journal Article
Silverberg, MJ; Leyden, WA; Lam, JO; Chao, CR; Gregorich, SE; Huchko, MJ; Kulasingam, S; Kuppermann, M; Smith-McCune, KK; Sawaya, GF
Published in: Vaccine
June 15, 2020

It is unknown whether the HPV vaccine is effective in immunocompromised women during catch-up ages. We performed a case-control study of 4,357 women with incident CIN2+ (cases) and 5:1 age-matched, incidence-density selected controls (N = 21,773) enrolled in an integrated health care system from 2006 to 2014. Vaccine effectiveness was estimated from multivariable conditional logistic regression models, with results stratified by immunosuppression history, defined as prior HIV infection, solid organ transplant history, or recently prescribed immunosuppressive medications. HPV vaccination resulted in a 19% reduction in CIN2+ rates for women without an immunosuppression history but a nonsignificant 4% reduction for women with an immunosuppression history. Further research is needed to evaluate whether catch-up HPV vaccine effectiveness varies by immunosuppression status, especially given the recent approval of the HPV vaccine for adults up to 45 years of age.

Duke Scholars

Published In

Vaccine

DOI

EISSN

1873-2518

Publication Date

June 15, 2020

Volume

38

Issue

29

Start / End Page

4520 / 4523

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccination
  • Uterine Cervical Neoplasms
  • Papillomavirus Vaccines
  • Papillomavirus Infections
  • Humans
  • HIV Infections
  • Female
  • Case-Control Studies
  • Alphapapillomavirus
 

Citation

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MLA
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Silverberg, M. J., Leyden, W. A., Lam, J. O., Chao, C. R., Gregorich, S. E., Huchko, M. J., … Sawaya, G. F. (2020). Effectiveness of 'catch-up' human papillomavirus vaccination to prevent cervical neoplasia in immunosuppressed and non-immunosuppressed women. Vaccine, 38(29), 4520–4523. https://doi.org/10.1016/j.vaccine.2020.05.004
Silverberg, Michael J., Wendy A. Leyden, Jennifer O. Lam, Chun R. Chao, Steven E. Gregorich, Megan J. Huchko, Shalini Kulasingam, Miriam Kuppermann, Karen K. Smith-McCune, and George F. Sawaya. “Effectiveness of 'catch-up' human papillomavirus vaccination to prevent cervical neoplasia in immunosuppressed and non-immunosuppressed women.Vaccine 38, no. 29 (June 15, 2020): 4520–23. https://doi.org/10.1016/j.vaccine.2020.05.004.
Silverberg MJ, Leyden WA, Lam JO, Chao CR, Gregorich SE, Huchko MJ, et al. Effectiveness of 'catch-up' human papillomavirus vaccination to prevent cervical neoplasia in immunosuppressed and non-immunosuppressed women. Vaccine. 2020 Jun 15;38(29):4520–3.
Silverberg, Michael J., et al. “Effectiveness of 'catch-up' human papillomavirus vaccination to prevent cervical neoplasia in immunosuppressed and non-immunosuppressed women.Vaccine, vol. 38, no. 29, June 2020, pp. 4520–23. Pubmed, doi:10.1016/j.vaccine.2020.05.004.
Silverberg MJ, Leyden WA, Lam JO, Chao CR, Gregorich SE, Huchko MJ, Kulasingam S, Kuppermann M, Smith-McCune KK, Sawaya GF. Effectiveness of 'catch-up' human papillomavirus vaccination to prevent cervical neoplasia in immunosuppressed and non-immunosuppressed women. Vaccine. 2020 Jun 15;38(29):4520–4523.
Journal cover image

Published In

Vaccine

DOI

EISSN

1873-2518

Publication Date

June 15, 2020

Volume

38

Issue

29

Start / End Page

4520 / 4523

Location

Netherlands

Related Subject Headings

  • Virology
  • Vaccination
  • Uterine Cervical Neoplasms
  • Papillomavirus Vaccines
  • Papillomavirus Infections
  • Humans
  • HIV Infections
  • Female
  • Case-Control Studies
  • Alphapapillomavirus