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STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement.

Publication ,  Journal Article
Little, J; Higgins, JPT; Ioannidis, JPA; Moher, D; Gagnon, F; von Elm, E; Khoury, MJ; Cohen, B; Davey-Smith, G; Grimshaw, J; Scheet, P ...
Published in: Ann Intern Med
February 3, 2009

Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information into the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the STrengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modeling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and issues of data volume that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.

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Published In

Ann Intern Med

DOI

EISSN

1539-3704

Publication Date

February 3, 2009

Volume

150

Issue

3

Start / End Page

206 / 215

Location

United States

Related Subject Headings

  • Research Design
  • Publishing
  • Guidelines as Topic
  • Genetic Research
  • General & Internal Medicine
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences
 

Citation

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Little, J., Higgins, J. P. T., Ioannidis, J. P. A., Moher, D., Gagnon, F., von Elm, E., … Birkett, N. (2009). STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement. Ann Intern Med, 150(3), 206–215. https://doi.org/10.7326/0003-4819-150-3-200902030-00011
Little, Julian, Julian P. T. Higgins, John P. A. Ioannidis, David Moher, France Gagnon, Erik von Elm, Muin J. Khoury, et al. “STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement.Ann Intern Med 150, no. 3 (February 3, 2009): 206–15. https://doi.org/10.7326/0003-4819-150-3-200902030-00011.
Little J, Higgins JPT, Ioannidis JPA, Moher D, Gagnon F, von Elm E, et al. STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement. Ann Intern Med. 2009 Feb 3;150(3):206–15.
Little, Julian, et al. “STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement.Ann Intern Med, vol. 150, no. 3, Feb. 2009, pp. 206–15. Pubmed, doi:10.7326/0003-4819-150-3-200902030-00011.
Little J, Higgins JPT, Ioannidis JPA, Moher D, Gagnon F, von Elm E, Khoury MJ, Cohen B, Davey-Smith G, Grimshaw J, Scheet P, Gwinn M, Williamson RE, Zou GY, Hutchings K, Johnson CY, Tait V, Wiens M, Golding J, van Duijn C, McLaughlin J, Paterson A, Wells G, Fortier I, Freedman M, Zecevic M, King R, Infante-Rivard C, Stewart A, Birkett N. STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement. Ann Intern Med. 2009 Feb 3;150(3):206–215.

Published In

Ann Intern Med

DOI

EISSN

1539-3704

Publication Date

February 3, 2009

Volume

150

Issue

3

Start / End Page

206 / 215

Location

United States

Related Subject Headings

  • Research Design
  • Publishing
  • Guidelines as Topic
  • Genetic Research
  • General & Internal Medicine
  • 3202 Clinical sciences
  • 11 Medical and Health Sciences