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Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.

Publication ,  Journal Article
Li, Y; Guptill, JT; Russo, MA; Howard, JF; Massey, JM; Juel, VC; Hobson-Webb, LD; Emmett, D; Chopra, M; Raja, S; Liu, W; Yi, JS
Published in: J Neuroimmunol
August 15, 2020

A detailed understanding of the role of Tfh cells in MuSK-antibody positive myasthenia gravis (MuSK-MG) is lacking. We characterized phenotype and function of Tfh cells in MuSK-MG patients and controls. We found similar overall Tfh and follicular regulatory (Tfr) T cell frequencies in MuSK-MG and healthy controls, but MuSK-MG patients exhibited higher frequencies of Tfh17 cells and a higher ratio of Tfh:Tfr cells. These results suggest imbalanced Tfh cell regulation, further supported by increased frequencies of CD4 T cells co-producing IL-21/IL-17 and IL-17/IFN-γ, and increased Tfh-supported IgG production. These results support a role for Tfh cell dysregulation in MuSK-MG immunopathology.

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Published In

J Neuroimmunol

DOI

EISSN

1872-8421

Publication Date

August 15, 2020

Volume

345

Start / End Page

577279

Location

Netherlands

Related Subject Headings

  • Young Adult
  • T-Lymphocytes, Helper-Inducer
  • Neurology & Neurosurgery
  • Myasthenia Gravis
  • Middle Aged
  • Male
  • Interleukin-17
  • Inflammation Mediators
  • Humans
  • Female
 

Citation

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Li, Y., Guptill, J. T., Russo, M. A., Howard, J. F., Massey, J. M., Juel, V. C., … Yi, J. S. (2020). Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis. J Neuroimmunol, 345, 577279. https://doi.org/10.1016/j.jneuroim.2020.577279
Li, Yingkai, Jeffrey T. Guptill, Melissa A. Russo, James F. Howard, Janice M. Massey, Vern C. Juel, Lisa D. Hobson-Webb, et al. “Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.J Neuroimmunol 345 (August 15, 2020): 577279. https://doi.org/10.1016/j.jneuroim.2020.577279.
Li Y, Guptill JT, Russo MA, Howard JF, Massey JM, Juel VC, et al. Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis. J Neuroimmunol. 2020 Aug 15;345:577279.
Li, Yingkai, et al. “Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.J Neuroimmunol, vol. 345, Aug. 2020, p. 577279. Pubmed, doi:10.1016/j.jneuroim.2020.577279.
Li Y, Guptill JT, Russo MA, Howard JF, Massey JM, Juel VC, Hobson-Webb LD, Emmett D, Chopra M, Raja S, Liu W, Yi JS. Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis. J Neuroimmunol. 2020 Aug 15;345:577279.
Journal cover image

Published In

J Neuroimmunol

DOI

EISSN

1872-8421

Publication Date

August 15, 2020

Volume

345

Start / End Page

577279

Location

Netherlands

Related Subject Headings

  • Young Adult
  • T-Lymphocytes, Helper-Inducer
  • Neurology & Neurosurgery
  • Myasthenia Gravis
  • Middle Aged
  • Male
  • Interleukin-17
  • Inflammation Mediators
  • Humans
  • Female