Design, methods, and conduct of the Optic Neuritis Treatment Trial.
Publication
, Journal Article
Cleary, PA; Beck, RW; Anderson, MM; Kenny, DJ; Backlund, JY; Gilbert, PR
Published in: Control Clin Trials
April 1993
The Optic Neuritis Treatment Trial (ONTT) was an investigator-initiated, multi-centered, randomized, controlled clinical trial supported by cooperative agreements and grants. It was designed to evaluate the efficacy and safety of oral prednisone or intravenous methylprednisolone followed by oral prednisone as compared with oral placebo. The primary outcome measures were contrast sensitivity and visual field; secondary measures were visual acuity and color vision. Four hundred fifty-seven patients were followed for a minimum of 6 months and a maximum of 3 years. This article describes the design and the methods used to implement the ONTT.
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Published In
Control Clin Trials
DOI
ISSN
0197-2456
Publication Date
April 1993
Volume
14
Issue
2
Start / End Page
123 / 142
Location
United States
Related Subject Headings
- Vision Disorders
- Treatment Outcome
- Public Health
- Prednisone
- Placebos
- Optic Neuritis
- Optic Nerve
- Middle Aged
- Methylprednisolone
- Male
Citation
APA
Chicago
ICMJE
MLA
NLM
Cleary, P. A., Beck, R. W., Anderson, M. M., Kenny, D. J., Backlund, J. Y., & Gilbert, P. R. (1993). Design, methods, and conduct of the Optic Neuritis Treatment Trial. Control Clin Trials, 14(2), 123–142. https://doi.org/10.1016/0197-2456(93)90015-6
Cleary, P. A., R. W. Beck, M. M. Anderson, D. J. Kenny, J. Y. Backlund, and P. R. Gilbert. “Design, methods, and conduct of the Optic Neuritis Treatment Trial.” Control Clin Trials 14, no. 2 (April 1993): 123–42. https://doi.org/10.1016/0197-2456(93)90015-6.
Cleary PA, Beck RW, Anderson MM, Kenny DJ, Backlund JY, Gilbert PR. Design, methods, and conduct of the Optic Neuritis Treatment Trial. Control Clin Trials. 1993 Apr;14(2):123–42.
Cleary, P. A., et al. “Design, methods, and conduct of the Optic Neuritis Treatment Trial.” Control Clin Trials, vol. 14, no. 2, Apr. 1993, pp. 123–42. Pubmed, doi:10.1016/0197-2456(93)90015-6.
Cleary PA, Beck RW, Anderson MM, Kenny DJ, Backlund JY, Gilbert PR. Design, methods, and conduct of the Optic Neuritis Treatment Trial. Control Clin Trials. 1993 Apr;14(2):123–142.
Published In
Control Clin Trials
DOI
ISSN
0197-2456
Publication Date
April 1993
Volume
14
Issue
2
Start / End Page
123 / 142
Location
United States
Related Subject Headings
- Vision Disorders
- Treatment Outcome
- Public Health
- Prednisone
- Placebos
- Optic Neuritis
- Optic Nerve
- Middle Aged
- Methylprednisolone
- Male