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Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study.

Publication ,  Journal Article
Oshunbade, AA; Yimer, WK; Valle, KA; Clark, D; Kamimura, D; White, WB; DeFilippis, AP; Blaha, MJ; Benjamin, EJ; O'Brien, EC; Mentz, RJ ...
Published in: J Am Heart Assoc
June 16, 2020

Background Blacks are disproportionately affected by stroke compared with whites; however, less is known about the relationship between stroke and cigarette smoking in blacks. Therefore, we evaluated the relationship between cigarette smoking and all incident stroke in the JHS (Jackson Heart Study). Methods and Results JHS participants without a history of stroke (n=4410) were classified by self-reported baseline smoking status into current, past (smoked at least 400 cigarettes/life), or never smokers at baseline (2000-2004). Current smokers were further classified by smoking intensity (number of cigarettes smoked per day [1-19 and ≥20]) and followed up for incident stroke (through 2015). Hazard ratios (HRs) for incident stroke for current and past smoking compared with never smoking were estimated with adjusted Cox proportional hazard regression models. After adjusting for cardiovascular risk factors, the risk for stroke in current smokers was significantly higher compared with never smokers (HR, 2.48; 95% CI, 1.60-3.83) but there was no significant difference between past smokers and never smokers (HR, 1.10; 95% CI, 0.74-1.64). There was a dose-dependent increased risk of stroke with smoking intensity (HR, 2.28 [95% CI, 1.38-3.86] and HR, 2.78 [95% CI, 1.47-5.28] for current smokers smoking 1-19 and ≥20 cigarettes/day, respectively). Conclusions In a large cohort of blacks, current cigarette smoking was associated with a dose-dependent higher risk of all stroke. In addition, past smokers did not have a significantly increased risk of all stroke compared with never smokers, which suggests that smoking cessation may have potential benefits in reducing the incidence of stroke in blacks.

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Published In

J Am Heart Assoc

DOI

EISSN

2047-9980

Publication Date

June 16, 2020

Volume

9

Issue

12

Start / End Page

e014990

Location

England

Related Subject Headings

  • Young Adult
  • Stroke
  • Smokers
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Non-Smokers
  • Mississippi
  • Middle Aged
  • Male
 

Citation

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Oshunbade, A. A., Yimer, W. K., Valle, K. A., Clark, D., Kamimura, D., White, W. B., … Hall, M. E. (2020). Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study. J Am Heart Assoc, 9(12), e014990. https://doi.org/10.1161/JAHA.119.014990
Oshunbade, Adebamike A., Wondwosen K. Yimer, Karen A. Valle, Donald Clark, Daisuke Kamimura, Wendy B. White, Andrew P. DeFilippis, et al. “Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study.J Am Heart Assoc 9, no. 12 (June 16, 2020): e014990. https://doi.org/10.1161/JAHA.119.014990.
Oshunbade AA, Yimer WK, Valle KA, Clark D, Kamimura D, White WB, et al. Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study. J Am Heart Assoc. 2020 Jun 16;9(12):e014990.
Oshunbade, Adebamike A., et al. “Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study.J Am Heart Assoc, vol. 9, no. 12, June 2020, p. e014990. Pubmed, doi:10.1161/JAHA.119.014990.
Oshunbade AA, Yimer WK, Valle KA, Clark D, Kamimura D, White WB, DeFilippis AP, Blaha MJ, Benjamin EJ, O’Brien EC, Mentz RJ, Fox ER, O’Mara CS, Butler J, Correa A, Hall ME. Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study. J Am Heart Assoc. 2020 Jun 16;9(12):e014990.
Journal cover image

Published In

J Am Heart Assoc

DOI

EISSN

2047-9980

Publication Date

June 16, 2020

Volume

9

Issue

12

Start / End Page

e014990

Location

England

Related Subject Headings

  • Young Adult
  • Stroke
  • Smokers
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Non-Smokers
  • Mississippi
  • Middle Aged
  • Male