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Injectable Therapies for Regional Melanoma.

Publication ,  Journal Article
Farrow, NE; Leddy, M; Landa, K; Beasley, GM
Published in: Surg Oncol Clin N Am
July 2020

Patients with unresectable cutaneous, subcutaneous, or nodal melanoma metastases are often candidates for injectable therapies, which are attractive for ease of intralesional delivery to superficial metastases and limited systemic toxicity profiles. Injectable or intralesional therapies can be part of multifaceted treatment strategies to kill tumor directly or to alter the tumor so as to make it more sensitive to systemic therapy. Talimogene laherparepvec is the only Food and Drug Administration-approved injectable therapy currently in wide clinical use in the United States, although ongoing trials are evaluating novel intralesional agents as well as combinations with systemic therapies, particularly checkpoint inhibitors.

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Published In

Surg Oncol Clin N Am

DOI

EISSN

1558-5042

Publication Date

July 2020

Volume

29

Issue

3

Start / End Page

433 / 444

Location

United States

Related Subject Headings

  • Oncolytic Virotherapy
  • Oncology & Carcinogenesis
  • Melanoma
  • Immunotherapy
  • Humans
  • Herpesvirus 1, Human
  • Biological Products
  • Antineoplastic Agents, Immunological
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
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ICMJE
MLA
NLM
Farrow, N. E., Leddy, M., Landa, K., & Beasley, G. M. (2020). Injectable Therapies for Regional Melanoma. Surg Oncol Clin N Am, 29(3), 433–444. https://doi.org/10.1016/j.soc.2020.02.008
Farrow, Norma E., Margaret Leddy, Karenia Landa, and Georgia M. Beasley. “Injectable Therapies for Regional Melanoma.Surg Oncol Clin N Am 29, no. 3 (July 2020): 433–44. https://doi.org/10.1016/j.soc.2020.02.008.
Farrow NE, Leddy M, Landa K, Beasley GM. Injectable Therapies for Regional Melanoma. Surg Oncol Clin N Am. 2020 Jul;29(3):433–44.
Farrow, Norma E., et al. “Injectable Therapies for Regional Melanoma.Surg Oncol Clin N Am, vol. 29, no. 3, July 2020, pp. 433–44. Pubmed, doi:10.1016/j.soc.2020.02.008.
Farrow NE, Leddy M, Landa K, Beasley GM. Injectable Therapies for Regional Melanoma. Surg Oncol Clin N Am. 2020 Jul;29(3):433–444.
Journal cover image

Published In

Surg Oncol Clin N Am

DOI

EISSN

1558-5042

Publication Date

July 2020

Volume

29

Issue

3

Start / End Page

433 / 444

Location

United States

Related Subject Headings

  • Oncolytic Virotherapy
  • Oncology & Carcinogenesis
  • Melanoma
  • Immunotherapy
  • Humans
  • Herpesvirus 1, Human
  • Biological Products
  • Antineoplastic Agents, Immunological
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis