Signaling Pathways Controlling Microglia Chemotaxis.
Publication
, Journal Article
Fan, Y; Xie, L; Chung, CY
Published in: Molecules and cells
March 2017
Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain's innate immune response against infection, injury, and diseases. Microglia respond to extracellular signals and engulf unwanted neuronal debris by phagocytosis, thereby maintaining normal cellular homeostasis in the CNS. Pathological stimuli such as neuronal injury induce transformation and activation of resting microglia with ramified morphology into a motile amoeboid form and activated microglia chemotax toward lesion site. This review outlines the current research on microglial activation and chemotaxis.
Published In
Molecules and cells
DOI
EISSN
0219-1032
ISSN
1016-8478
Publication Date
March 2017
Volume
40
Issue
3
Start / End Page
163 / 168
Related Subject Headings
- Signal Transduction
- Microglia
- Humans
- Chemotaxis
- Central Nervous System
- Cell Movement
- Biochemistry & Molecular Biology
- Animals
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Fan, Y., Xie, L., & Chung, C. Y. (2017). Signaling Pathways Controlling Microglia Chemotaxis. Molecules and Cells, 40(3), 163–168. https://doi.org/10.14348/molcells.2017.0011
Fan, Yang, Lirui Xie, and Chang Y. Chung. “Signaling Pathways Controlling Microglia Chemotaxis.” Molecules and Cells 40, no. 3 (March 2017): 163–68. https://doi.org/10.14348/molcells.2017.0011.
Fan Y, Xie L, Chung CY. Signaling Pathways Controlling Microglia Chemotaxis. Molecules and cells. 2017 Mar;40(3):163–8.
Fan, Yang, et al. “Signaling Pathways Controlling Microglia Chemotaxis.” Molecules and Cells, vol. 40, no. 3, Mar. 2017, pp. 163–68. Epmc, doi:10.14348/molcells.2017.0011.
Fan Y, Xie L, Chung CY. Signaling Pathways Controlling Microglia Chemotaxis. Molecules and cells. 2017 Mar;40(3):163–168.
Published In
Molecules and cells
DOI
EISSN
0219-1032
ISSN
1016-8478
Publication Date
March 2017
Volume
40
Issue
3
Start / End Page
163 / 168
Related Subject Headings
- Signal Transduction
- Microglia
- Humans
- Chemotaxis
- Central Nervous System
- Cell Movement
- Biochemistry & Molecular Biology
- Animals
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology