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EPCR knockout: inflaming the discussion.

Publication ,  Journal Article
Monroe, D; Hoffman, M
Published in: Blood
June 18, 2020

In this issue of Blood, Magisetty et al provide some surprising results from their studies of the role of endothelial protein C receptor (EPCR) in hemophilic arthropathy. There is a rationale for studying EPCR in hemophilia. It is well recognized that EPCR promotes the activation of protein C (PC) to activated PC (aPC) on endothelial surfaces. The aPC has antithrombotic effects by inactivating factor Va (FVa) on nearby endothelial surfaces. Like aPC, activated coagulation FVIIa can also bind to EPCR. Pavani et al showed that binding to EPCR enhances the hemostatic effect of FVIIa in a mouse hemophilia model, when assayed as ferric chloride–induced thrombosis. The Rao group showed that hemostatic levels of FVIIa displace PC from EPCR, and blockade of EPCR reduces the level of FVIIa needed for hemostasis in a saphenous vein bleeding assay. However, they reported that EPCR blockade by itself did not reduce the severity of bleeding in hemophilic mice. They concluded that downregulation of aPC generation is the major mechanism by which FVIIa interaction with EPCR contributes to the hemostatic effect of FVIIa in hemophilia.

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Published In

Blood

DOI

EISSN

1528-0020

Publication Date

June 18, 2020

Volume

135

Issue

25

Start / End Page

2201 / 2202

Location

United States

Related Subject Headings

  • Receptors, Cell Surface
  • Protein C
  • Mice
  • Immunology
  • Hemophilia A
  • Endothelial Protein C Receptor
  • Animals
  • 3213 Paediatrics
  • 3201 Cardiovascular medicine and haematology
  • 3101 Biochemistry and cell biology
 

Citation

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Monroe, D., & Hoffman, M. (2020). EPCR knockout: inflaming the discussion. Blood, 135(25), 2201–2202. https://doi.org/10.1182/blood.2020006001
Monroe, Dougald, and Maureane Hoffman. “EPCR knockout: inflaming the discussion.Blood 135, no. 25 (June 18, 2020): 2201–2. https://doi.org/10.1182/blood.2020006001.
Monroe D, Hoffman M. EPCR knockout: inflaming the discussion. Blood. 2020 Jun 18;135(25):2201–2.
Monroe, Dougald, and Maureane Hoffman. “EPCR knockout: inflaming the discussion.Blood, vol. 135, no. 25, June 2020, pp. 2201–02. Pubmed, doi:10.1182/blood.2020006001.
Monroe D, Hoffman M. EPCR knockout: inflaming the discussion. Blood. 2020 Jun 18;135(25):2201–2202.

Published In

Blood

DOI

EISSN

1528-0020

Publication Date

June 18, 2020

Volume

135

Issue

25

Start / End Page

2201 / 2202

Location

United States

Related Subject Headings

  • Receptors, Cell Surface
  • Protein C
  • Mice
  • Immunology
  • Hemophilia A
  • Endothelial Protein C Receptor
  • Animals
  • 3213 Paediatrics
  • 3201 Cardiovascular medicine and haematology
  • 3101 Biochemistry and cell biology