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The ECG Belt for CRT response trial: Design and clinical protocol.

Publication ,  Journal Article
Rickard, J; Jackson, K; Biffi, M; Vernooy, K; Bank, A; Cerkvenik, J; Ghosh, S; Gold, MR
Published in: Pacing Clin Electrophysiol
October 2020

The ECG Belt for CRT response trial is designed to test the hypothesis that in patients traditionally less likely to respond to cardiac resynchronization therapy (CRT), an individualized approach utilizing the electrocardiogram (ECG) Belt to guide lead placement, vector selection, and device programming is superior to current standard of care. The ECG Belt is a noninvasive mapping technology designed to measure beat by beat electrical activation of the left ventricle by utilizing unipolar measurements from multiple ECG electrodes on the body surface. The ECG Belt for CRT response trial is a multicenter, prospective, randomized, investigational pre-market research study conducted at 48 centers in the United States, Canada, and Europe and will randomize approximately 400 subjects. The trial has three arms (enrollment will be 2:1:1, respectively): utilization of the Belt to guide implant as well as postimplant programming, utilizing the Belt to guide postimplant programming alone, and a non-Belt control arm. AdaptivCRT will be an option in the treatment arm but not the control arms. The primary endpoint is change in left ventricular end-systolic volume between preimplant and at 6 months. This paper describes the design and analytic plan for the trial.

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Published In

Pacing Clin Electrophysiol

DOI

EISSN

1540-8159

Publication Date

October 2020

Volume

43

Issue

10

Start / End Page

1063 / 1071

Location

United States

Related Subject Headings

  • Software
  • Research Design
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Multicenter Studies as Topic
  • Male
  • Humans
  • Heart Failure
  • Female
  • Electrocardiography
 

Citation

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Rickard, J., Jackson, K., Biffi, M., Vernooy, K., Bank, A., Cerkvenik, J., … Gold, M. R. (2020). The ECG Belt for CRT response trial: Design and clinical protocol. Pacing Clin Electrophysiol, 43(10), 1063–1071. https://doi.org/10.1111/pace.13985
Rickard, John, Kevin Jackson, Mauro Biffi, Kevin Vernooy, Alan Bank, Jeff Cerkvenik, Subham Ghosh, and Michael R. Gold. “The ECG Belt for CRT response trial: Design and clinical protocol.Pacing Clin Electrophysiol 43, no. 10 (October 2020): 1063–71. https://doi.org/10.1111/pace.13985.
Rickard J, Jackson K, Biffi M, Vernooy K, Bank A, Cerkvenik J, et al. The ECG Belt for CRT response trial: Design and clinical protocol. Pacing Clin Electrophysiol. 2020 Oct;43(10):1063–71.
Rickard, John, et al. “The ECG Belt for CRT response trial: Design and clinical protocol.Pacing Clin Electrophysiol, vol. 43, no. 10, Oct. 2020, pp. 1063–71. Pubmed, doi:10.1111/pace.13985.
Rickard J, Jackson K, Biffi M, Vernooy K, Bank A, Cerkvenik J, Ghosh S, Gold MR. The ECG Belt for CRT response trial: Design and clinical protocol. Pacing Clin Electrophysiol. 2020 Oct;43(10):1063–1071.

Published In

Pacing Clin Electrophysiol

DOI

EISSN

1540-8159

Publication Date

October 2020

Volume

43

Issue

10

Start / End Page

1063 / 1071

Location

United States

Related Subject Headings

  • Software
  • Research Design
  • Randomized Controlled Trials as Topic
  • Prospective Studies
  • Multicenter Studies as Topic
  • Male
  • Humans
  • Heart Failure
  • Female
  • Electrocardiography