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Clinical, Imaging Findings, Responses, and Outcomes of Patients With Classical Hodgkin Lymphoma and Non-Hodgkin Lymphoma Undergoing Immune Checkpoint Inhibitor Therapy: A Single-Institution Experience.

Publication ,  Journal Article
Liput, J; Guler, E; Smith, DA; Tirumani, SH; Hoimes, C; Caimi, PF; Ramaiya, NH
Published in: J Comput Assist Tomogr
2020

OBJECTIVE: The aim of the study was to study clinical, imaging findings, response patterns, and immune-related adverse events in classical Hodgkin lymphoma (cHL) and non-Hodgkin lymphoma (NHL) patients treated with immune checkpoint inhibitors (ICIs). METHODS: A retrospective search was performed to identify patients with relapsed/refractory cHL and NHL treated with ICIs from 2015 to 2019. Clinical and laboratory data were collected. Imaging studies were reviewed for treatment response and immune-related adverse events. RESULTS: Ten patients with relapsed/refractory cHL (median age, 41 years) and 14 patients with relapsed/refractory NHL (median age, 61 years) were identified. Overall response rate was 70% for cHL patients. None of the NHL patients demonstrated complete or partial response. One case of hyperprogression and one case with atypical response were radiologically detected in cHL patients. Hypothyroidism requiring treatment occurred in 2 (20%) of 10 cHL patients, one of which had imaging correlate. Of 14 NHL patients, 1 (7%) had radiologic evidence of pneumonitis and 1 (7%) had colitis. CONCLUSIONS: This single-institution observational study demonstrated that overall response rate was higher in patients with cHL undergoing ICI. Immune checkpoint inhibitor therapy has unique response patterns and toxicities in both cHL and NHL patients that radiologists should keep in mind.

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Published In

J Comput Assist Tomogr

DOI

EISSN

1532-3145

Publication Date

2020

Volume

44

Issue

4

Start / End Page

619 / 626

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Tertiary Care Centers
  • Survival Analysis
  • Retrospective Studies
  • Radiographic Image Interpretation, Computer-Assisted
  • Pneumonia
  • Nuclear Medicine & Medical Imaging
  • Nivolumab
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liput, J., Guler, E., Smith, D. A., Tirumani, S. H., Hoimes, C., Caimi, P. F., & Ramaiya, N. H. (2020). Clinical, Imaging Findings, Responses, and Outcomes of Patients With Classical Hodgkin Lymphoma and Non-Hodgkin Lymphoma Undergoing Immune Checkpoint Inhibitor Therapy: A Single-Institution Experience. J Comput Assist Tomogr, 44(4), 619–626. https://doi.org/10.1097/RCT.0000000000001043
Liput, Joseph, Ezgi Guler, Daniel A. Smith, Sree Harsha Tirumani, Christopher Hoimes, Paolo F. Caimi, and Nikhil H. Ramaiya. “Clinical, Imaging Findings, Responses, and Outcomes of Patients With Classical Hodgkin Lymphoma and Non-Hodgkin Lymphoma Undergoing Immune Checkpoint Inhibitor Therapy: A Single-Institution Experience.J Comput Assist Tomogr 44, no. 4 (2020): 619–26. https://doi.org/10.1097/RCT.0000000000001043.

Published In

J Comput Assist Tomogr

DOI

EISSN

1532-3145

Publication Date

2020

Volume

44

Issue

4

Start / End Page

619 / 626

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Tertiary Care Centers
  • Survival Analysis
  • Retrospective Studies
  • Radiographic Image Interpretation, Computer-Assisted
  • Pneumonia
  • Nuclear Medicine & Medical Imaging
  • Nivolumab
  • Middle Aged