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Sex differences in response to nicotine in C57Bl/6:129SvEv mice.

Publication ,  Journal Article
Isiegas, C; Mague, SD; Blendy, JA
Published in: Nicotine Tob Res
July 2009

INTRODUCTION: Human studies suggest that smoking behavior in men may depend more on the pharmacological effects of nicotine, whereas in women, this behavior may rely more on nonpharmacological factors associated with smoking. Investigation of these parameters in mice may also reveal sex differences. METHODS: Male and female C57Bl/6:129SvEv hybrid mice were exposed to increasing concentrations of nicotine in a voluntary oral nicotine consumption paradigm in which we measured fluid consumption over time and dose. Separate cohorts of mice were exposed to nicotine in a place-conditioning paradigm, and preference was determined. These behavioral models were used to examine sex differences in mice as they rely on pharmacological as well as nonpharmacological factors. Mice exposed to nicotine or saline also were tested for sex differences in locomotor-activating effects of nicotine and in analgesia using standard activity monitoring and hot-plate tests. RESULTS: Females responded more to the conditioned rewarding effects of nicotine compared with males. Males, however, seemed more responsive to the pharmacological aspects of nicotine by reducing nicotine drinking at higher concentrations; females maintained consistent levels of intake over several doses of nicotine. Male and female mice demonstrated similar locomotor and antinociceptive responses to nicotine. DISCUSSION: These data suggest that place-conditioning and two-bottle choice paradigms may be more sensitive measures of sexual dimorphism in the C57BL/6:129SvEv hybrid mouse than are locomotor or nociception assays.

Duke Scholars

Published In

Nicotine Tob Res

DOI

EISSN

1469-994X

Publication Date

July 2009

Volume

11

Issue

7

Start / End Page

851 / 858

Location

England

Related Subject Headings

  • Species Specificity
  • Sex Factors
  • Sex Characteristics
  • Public Health
  • Nicotine
  • Motor Activity
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Female
 

Citation

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Isiegas, C., Mague, S. D., & Blendy, J. A. (2009). Sex differences in response to nicotine in C57Bl/6:129SvEv mice. Nicotine Tob Res, 11(7), 851–858. https://doi.org/10.1093/ntr/ntp076
Isiegas, Carolina, Stephen D. Mague, and Julie A. Blendy. “Sex differences in response to nicotine in C57Bl/6:129SvEv mice.Nicotine Tob Res 11, no. 7 (July 2009): 851–58. https://doi.org/10.1093/ntr/ntp076.
Isiegas C, Mague SD, Blendy JA. Sex differences in response to nicotine in C57Bl/6:129SvEv mice. Nicotine Tob Res. 2009 Jul;11(7):851–8.
Isiegas, Carolina, et al. “Sex differences in response to nicotine in C57Bl/6:129SvEv mice.Nicotine Tob Res, vol. 11, no. 7, July 2009, pp. 851–58. Pubmed, doi:10.1093/ntr/ntp076.
Isiegas C, Mague SD, Blendy JA. Sex differences in response to nicotine in C57Bl/6:129SvEv mice. Nicotine Tob Res. 2009 Jul;11(7):851–858.
Journal cover image

Published In

Nicotine Tob Res

DOI

EISSN

1469-994X

Publication Date

July 2009

Volume

11

Issue

7

Start / End Page

851 / 858

Location

England

Related Subject Headings

  • Species Specificity
  • Sex Factors
  • Sex Characteristics
  • Public Health
  • Nicotine
  • Motor Activity
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Female