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Intermittent but not sustained moderate hypoxia elicits long-term facilitation of hypoglossal motor output.

Publication ,  Journal Article
Wilkerson, JER; Devinney, M; Mitchell, GS
Published in: Respir Physiol Neurobiol
October 2018

Phrenic long-term facilitation (pLTF) is a form of serotonin-dependent respiratory motor plasticity induced by moderate acute intermittent hypoxia (AIH), but not by moderate acute sustained hypoxia (ASH) of similar cumulative duration. Thus, moderate AIH-induced pLTF is sensitive to the pattern of hypoxia. On the other hand, pLTF induced by severe AIH protocols is neither pattern sensitive nor serotonin dependent (it converts to an adenosine-dependent mechanism). Although moderate AIH also induces hypoglossal LTF (hLTF), no data are available concerning its sensitivity/insensitivity to the pattern of hypoxia. Since hLTF following moderate hypoxia is serotonin-dependent, we hypothesized that hLTF is pattern-sensitive, similar to serotonin-dependent pLTF. Integrated hypoglossal nerve activity was recorded in urethane-anesthetized, vagotomized, paralyzed, and ventilated rats exposed to isocapnic AIH (3, 5min episodes of 11% O2) or ASH (a single 25min episode of 11% O2). Similar to previous studies of pLTF, hypoglossal motor output was elevated for more than 1h following AIH (50±20%, p<0.01), but not ASH (-6±9%, p>0.05). Frequency LTF was not observed following either hypoxic exposure. Thus, in agreement with our hypothesis, hypoglossal LTF following moderate AIH is pattern-sensitive, similar to phrenic LTF.

Duke Scholars

Published In

Respir Physiol Neurobiol

DOI

EISSN

1878-1519

Publication Date

October 2018

Volume

256

Start / End Page

15 / 20

Location

Netherlands

Related Subject Headings

  • Vagotomy
  • Time Factors
  • Rats, Sprague-Dawley
  • Rats
  • Physiology
  • Phrenic Nerve
  • Male
  • Hypoxia
  • Hypoglossal Nerve
  • Blood Pressure
 

Citation

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Wilkerson, J. E. R., Devinney, M., & Mitchell, G. S. (2018). Intermittent but not sustained moderate hypoxia elicits long-term facilitation of hypoglossal motor output. Respir Physiol Neurobiol, 256, 15–20. https://doi.org/10.1016/j.resp.2017.10.005
Wilkerson, Julia E. R., Michael Devinney, and Gordon S. Mitchell. “Intermittent but not sustained moderate hypoxia elicits long-term facilitation of hypoglossal motor output.Respir Physiol Neurobiol 256 (October 2018): 15–20. https://doi.org/10.1016/j.resp.2017.10.005.
Wilkerson JER, Devinney M, Mitchell GS. Intermittent but not sustained moderate hypoxia elicits long-term facilitation of hypoglossal motor output. Respir Physiol Neurobiol. 2018 Oct;256:15–20.
Wilkerson, Julia E. R., et al. “Intermittent but not sustained moderate hypoxia elicits long-term facilitation of hypoglossal motor output.Respir Physiol Neurobiol, vol. 256, Oct. 2018, pp. 15–20. Pubmed, doi:10.1016/j.resp.2017.10.005.
Wilkerson JER, Devinney M, Mitchell GS. Intermittent but not sustained moderate hypoxia elicits long-term facilitation of hypoglossal motor output. Respir Physiol Neurobiol. 2018 Oct;256:15–20.
Journal cover image

Published In

Respir Physiol Neurobiol

DOI

EISSN

1878-1519

Publication Date

October 2018

Volume

256

Start / End Page

15 / 20

Location

Netherlands

Related Subject Headings

  • Vagotomy
  • Time Factors
  • Rats, Sprague-Dawley
  • Rats
  • Physiology
  • Phrenic Nerve
  • Male
  • Hypoxia
  • Hypoglossal Nerve
  • Blood Pressure