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Mechanisms Contributing to the Progression of Ischemic and Nonischemic Dilated Cardiomyopathy: Possible Modulating Effects of Paracrine Activities of Stem Cells.

Publication ,  Journal Article
Kelkar, AA; Butler, J; Schelbert, EB; Greene, SJ; Quyyumi, AA; Bonow, RO; Cohen, I; Gheorghiade, M; Lipinski, MJ; Sun, W; Luger, D; Epstein, SE
Published in: J Am Coll Cardiol
November 3, 2015

Over the past 1.5 decades, numerous stem cell trials have been performed in patients with cardiovascular disease. Although encouraging outcome signals have been reported, these have been small, leading to uncertainty as to whether they will translate into significantly improved outcomes. A reassessment of the rationale for the use of stem cells in cardiovascular disease is therefore timely. Such a rationale should include analyses of why previous trials have not produced significant benefit and address whether mechanisms contributing to disease progression might benefit from known activities of stem cells. The present paper provides such a reassessment, focusing on patients with left ventricular systolic dysfunction, either nonischemic or ischemic. We conclude that many mechanisms contributing to progressive left ventricular dysfunction are matched by stem cell activities that could attenuate the myocardial effect of such mechanisms. This suggests that stem cell strategies may improve patient outcomes and justifies further testing.

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Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

November 3, 2015

Volume

66

Issue

18

Start / End Page

2038 / 2047

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Stem Cell Transplantation
  • Outcome Assessment, Health Care
  • Myocardial Ischemia
  • Humans
  • Disease Progression
  • Cardiovascular System & Hematology
  • Cardiomyopathy, Dilated
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
 

Citation

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Kelkar, A. A., Butler, J., Schelbert, E. B., Greene, S. J., Quyyumi, A. A., Bonow, R. O., … Epstein, S. E. (2015). Mechanisms Contributing to the Progression of Ischemic and Nonischemic Dilated Cardiomyopathy: Possible Modulating Effects of Paracrine Activities of Stem Cells. J Am Coll Cardiol, 66(18), 2038–2047. https://doi.org/10.1016/j.jacc.2015.09.010
Kelkar, Anita A., Javed Butler, Erik B. Schelbert, Stephen J. Greene, Arshed A. Quyyumi, Robert O. Bonow, Ira Cohen, et al. “Mechanisms Contributing to the Progression of Ischemic and Nonischemic Dilated Cardiomyopathy: Possible Modulating Effects of Paracrine Activities of Stem Cells.J Am Coll Cardiol 66, no. 18 (November 3, 2015): 2038–47. https://doi.org/10.1016/j.jacc.2015.09.010.
Kelkar AA, Butler J, Schelbert EB, Greene SJ, Quyyumi AA, Bonow RO, et al. Mechanisms Contributing to the Progression of Ischemic and Nonischemic Dilated Cardiomyopathy: Possible Modulating Effects of Paracrine Activities of Stem Cells. J Am Coll Cardiol. 2015 Nov 3;66(18):2038–47.
Kelkar, Anita A., et al. “Mechanisms Contributing to the Progression of Ischemic and Nonischemic Dilated Cardiomyopathy: Possible Modulating Effects of Paracrine Activities of Stem Cells.J Am Coll Cardiol, vol. 66, no. 18, Nov. 2015, pp. 2038–47. Pubmed, doi:10.1016/j.jacc.2015.09.010.
Kelkar AA, Butler J, Schelbert EB, Greene SJ, Quyyumi AA, Bonow RO, Cohen I, Gheorghiade M, Lipinski MJ, Sun W, Luger D, Epstein SE. Mechanisms Contributing to the Progression of Ischemic and Nonischemic Dilated Cardiomyopathy: Possible Modulating Effects of Paracrine Activities of Stem Cells. J Am Coll Cardiol. 2015 Nov 3;66(18):2038–2047.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

November 3, 2015

Volume

66

Issue

18

Start / End Page

2038 / 2047

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Stem Cell Transplantation
  • Outcome Assessment, Health Care
  • Myocardial Ischemia
  • Humans
  • Disease Progression
  • Cardiovascular System & Hematology
  • Cardiomyopathy, Dilated
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services