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Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE.

Publication ,  Journal Article
Umbleja, T; Brown, TT; Overton, ET; Ribaudo, HJ; Schrack, JA; Fitch, KV; Douglas, PS; Grinspoon, SK; Henn, S; Arduino, RC; Rodriguez, B ...
Published in: J Infect Dis
July 9, 2020

BACKGROUND: People with human immunodeficiency virus (PWH) are at risk for accelerated development of physical function impairment and frailty; both associated with increased risk of falls, hospitalizations, and death. Identifying factors associated with physical function impairment and frailty can help target interventions. METHODS: The REPRIEVE trial enrolled participants 40-75 years of age, receiving stable antiretroviral therapy with CD4+ T-cell count >100 cells/mm3, and with low to moderate cardiovascular disease risk. We conducted a cross-sectional analysis of those concurrently enrolled in the ancillary study PREPARE at enrollment. RESULTS: Among the 266 participants, the median age was 51 years; 81% were male, and 45% were black, and 28% had hypertension. Body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) was 25 to <30 in 38% and ≥30 in 30%, 33% had a high waist circumference, 89% were physically inactive, 37% (95% confidence interval, 31%, 43%) had physical function impairment (Short Physical Performance Battery score ≤10), and 6% (4%, 9%) were frail and 42% prefrail. In the adjusted analyses, older age, black race, greater BMI, and physical inactivity were associated with physical function impairment; depression and hypertension were associated with frailty or prefrailty. CONCLUSIONS: Physical function impairment was common among middle-aged PWH; greater BMI and physical inactivity are important modifiable factors that may prevent further decline in physical function with aging. CLINICAL TRIALS REGISTRATION: NCT02344290.

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Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

July 9, 2020

Volume

222

Issue

Suppl 1

Start / End Page

S52 / S62

Location

United States

Related Subject Headings

  • Sedentary Behavior
  • Race Factors
  • Prevalence
  • Physical Functional Performance
  • Middle Aged
  • Microbiology
  • Male
  • Humans
  • HIV Long-Term Survivors
  • HIV Infections
 

Citation

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Umbleja, T., Brown, T. T., Overton, E. T., Ribaudo, H. J., Schrack, J. A., Fitch, K. V., … Erlandson, K. M. (2020). Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE. J Infect Dis, 222(Suppl 1), S52–S62. https://doi.org/10.1093/infdis/jiaa249
Umbleja, Triin, Todd T. Brown, Edgar T. Overton, Heather J. Ribaudo, Jennifer A. Schrack, Kathleen V. Fitch, Pamela S. Douglas, et al. “Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE.J Infect Dis 222, no. Suppl 1 (July 9, 2020): S52–62. https://doi.org/10.1093/infdis/jiaa249.
Umbleja T, Brown TT, Overton ET, Ribaudo HJ, Schrack JA, Fitch KV, et al. Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE. J Infect Dis. 2020 Jul 9;222(Suppl 1):S52–62.
Umbleja, Triin, et al. “Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE.J Infect Dis, vol. 222, no. Suppl 1, July 2020, pp. S52–62. Pubmed, doi:10.1093/infdis/jiaa249.
Umbleja T, Brown TT, Overton ET, Ribaudo HJ, Schrack JA, Fitch KV, Douglas PS, Grinspoon SK, Henn S, Arduino RC, Rodriguez B, Benson CA, Erlandson KM. Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE. J Infect Dis. 2020 Jul 9;222(Suppl 1):S52–S62.
Journal cover image

Published In

J Infect Dis

DOI

EISSN

1537-6613

Publication Date

July 9, 2020

Volume

222

Issue

Suppl 1

Start / End Page

S52 / S62

Location

United States

Related Subject Headings

  • Sedentary Behavior
  • Race Factors
  • Prevalence
  • Physical Functional Performance
  • Middle Aged
  • Microbiology
  • Male
  • Humans
  • HIV Long-Term Survivors
  • HIV Infections